DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and ADGRL1

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_016881964.1 Gene:ADGRL1 / 22859 HGNCID:20973 Length:1506 Species:Homo sapiens


Alignment Length:344 Identity:83/344 - (24%)
Similarity:136/344 - (39%) Gaps:73/344 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 NHELPGNEFTLFENGSLLRHWDK-----VELSK-REYCV-QHLSFKDDSIRIAPHFCPLSSEHS- 211
            ||......|..:...|:|.:|..     ||.:| ...|. .||:          :|..|.:... 
Human   804 NHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLT----------NFAVLMAHREI 858

  Fly   212 ------------RTWKTVAIVISLICIILTISVYLYVEKL---RNLHGK--CFICYLASLFLGYF 259
                        .||  |.|||||:|:.:.||.:.::..|   ||...|  |...:||.|.   |
Human   859 YQGRINELLLSVITW--VGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELL---F 918

  Fly   260 FLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSV----ISLTLWNSFSGNSSWLNRFLPQNRFLS 320
            .:.::..:|.....:.||.|.|| .:|||.||.:    :.|.|...|....|         |...
Human   919 LVGIDKTQYEIACPIFAGLLHYF-FLAAFSWLCLEGVHLYLLLVEVFESEYS---------RTKY 973

  Fly   321 YNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITM 385
            |.|..:....|:..|....|.        ...|..|.||:.. |...:..|.||:..:||.|:..
Human   974 YYLGGYCFPALVVGIAAAIDY--------RSYGTEKACWLRV-DNYFIWSFIGPVSFVIVVNLVF 1029

  Fly   386 FVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWA 450
            .::|..::::      :.:..:..::||::.|......:.|..::||:|:..:: |:..::...|
Human  1030 LMVTLHKMIR------SSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLL-FINKESVVMA 1087

  Fly   451 KAFMVADYFNWSQGTVIFL 469
            ..|..   ||..||..||:
Human  1088 YLFTT---FNAFQGVFIFV 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 12/55 (22%)
7tm_4 216..436 CDD:304433 58/228 (25%)
ADGRL1XP_016881964.1 Gal_Lectin 48..128 CDD:396628
OLF 143..399 CDD:413369
PHA03247 <399..503 CDD:223021
HormR 484..547 CDD:214468
GAIN 557..782 CDD:406802
GPS 806..858 CDD:197639 12/61 (20%)
7tmB2_Latrophilin-1 865..1122 CDD:320673 69/273 (25%)
TM helix 1 868..892 CDD:320673 11/25 (44%)
TM helix 2 901..922 CDD:320673 7/23 (30%)
TM helix 3 932..954 CDD:320673 10/22 (45%)
TM helix 4 973..989 CDD:320673 3/15 (20%)
TM helix 5 1008..1031 CDD:320673 7/22 (32%)
TM helix 6 1058..1080 CDD:320673 5/22 (23%)
TM helix 7 1084..1109 CDD:320673 8/23 (35%)
Latrophilin 1121..1506 CDD:396778
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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