DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgrf5

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_006524187.1 Gene:Adgrf5 / 224792 MGIID:2182928 Length:1406 Species:Mus musculus


Alignment Length:456 Identity:100/456 - (21%)
Similarity:177/456 - (38%) Gaps:130/456 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 PQ-YQK---MQKSKCYGDMSEDE--LNKHDPFVNVTLSDGSVV----------------RRHFKE 135
            || ||:   .:.|..:||::.||  |....|       |.|:|                |:....
Mouse   920 PQIYQQQFIFKDSDLWGDVAIDECQLGNLQP-------DSSIVTVAFPTLKAILAQDVQRKTSSN 977

  Fly   136 DLI----VQSDLAKPGCPRMYFL-NHELPGNEFTLFENGSLLRH---WDKVELS---------KR 183
            .|:    |..::.||....|.|. ||...|....:|.|.||..:   ||....|         .|
Mouse   978 SLVMTTTVSHNIVKPFRISMTFKNNHRSGGKPQCVFWNFSLANNTGGWDSSGCSVEDDGRDNRDR 1042

  Fly   184 EYC-VQHL-SFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISLI-----------CIILTISVYLY 235
            .:| ..|| ||   ||.::|.    |.:.....|.:..:||.|           |:::...|:..
Mouse  1043 VFCKCNHLTSF---SILMSPD----SPDPGSLLKILLDIISYIGLGFSIVSLAACLVVEAMVWKS 1100

  Fly   236 VEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYSSG------------FCVTAGFLGYFSVIAAF 288
            |.|.|.    .::.::..:.:.:..|:.::|...:|            .||.|.|..:|..::.|
Mouse  1101 VTKNRT----SYMRHICIVNIAFCLLIADIWFIVAGAIHDGRYPLNETACVAATFFIHFFYLSVF 1161

  Fly   289 FWLSVISLTLWNSF------SGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEK 347
            ||:..:.|.|:...      :..|:        .:.::::| .:|..|::::||....|      
Mouse  1162 FWMLTLGLMLFYRLIFILHDASKST--------QKAIAFSL-GYGCPLIISSITVGVTQ------ 1211

  Fly   348 LRPR-VGVGKN-CWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKV-------KKEAQNF 403
              |: |.:.|| ||:...|...::.|..|.|:|:|.|:::.|:...:|::.       |:|..:.
Mouse  1212 --PQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVSITVVVITKILRPSIGDKPGKQEKSSL 1274

  Fly   404 TQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIF 468
            .|..|:...|..             ::||:|...:.:.:...|..:...|.:.:.|   ||..|.
Mouse  1275 FQISKSIGVLTP-------------LLGLTWGFGLATVIQGSNAVFHIIFTLLNAF---QGLFIL 1323

  Fly   469 L 469
            |
Mouse  1324 L 1324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 40/151 (26%)
7tm_4 216..436 CDD:304433 51/257 (20%)
Adgrf5XP_006524187.1 IG 301..375 CDD:214652
ig 535..608 CDD:365836
GPS 1009..1056 CDD:366827 14/49 (29%)
7tm_GPCRs 1070..1343 CDD:391938 58/292 (20%)
TM helix 1 1071..1096 CDD:341315 4/24 (17%)
TM helix 2 1111..1133 CDD:341315 2/21 (10%)
TM helix 3 1147..1170 CDD:341315 7/22 (32%)
TM helix 4 1190..1206 CDD:341315 3/16 (19%)
TM helix 5 1228..1251 CDD:341315 7/22 (32%)
TM helix 6 1275..1300 CDD:341315 6/37 (16%)
TM helix 7 1305..1330 CDD:341315 6/23 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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