DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and ADGRG3

DIOPT Version :10

Sequence 1:NP_663308.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_005255899.1 Gene:ADGRG3 / 222487 HGNCID:13728 Length:596 Species:Homo sapiens


Alignment Length:572 Identity:109/572 - (19%)
Similarity:192/572 - (33%) Gaps:197/572 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TAFLLLLLQN---SNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSK 70
            |.||..|:||   :.||    ||:.:::.|:.||                       :::.|:.|
Human    89 TPFLKALVQNLSTNTAE----DFYFSLEPSQVPR-----------------------QVMKDEDK 126

  Fly    71 EKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYG---------------DMSEDELNKHDPFVN 120
            .                     |...::.||....               |:....|.|..   .
Human   127 P---------------------PDRVRLPKSLFRSLPGNRSVVRLAVTILDIGPGTLFKGP---R 167

  Fly   121 VTLSDGSVVRRHFKEDLIV-QSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKRE 184
            :.|.|||.|..:....|.| |..:.|...|.....:|:.|....||     ....||..:.:..:
Human   168 LGLGDGSGVLNNRLVGLSVGQMHVTKLAEPLEIVFSHQRPPPNMTL-----TCVFWDVTKGTTGD 227

  Fly   185 Y----------------CVQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVA-IVISLICIILTISV 232
            :                |..||:|  .::.:.|.. ..|:.|..|..:.| ..:|:|.:..||.:
Human   228 WSSEGCSTEVRPEGTVCCCDHLTF--FALLLRPTL-DQSTVHILTRISQAGCGVSMIFLAFTIIL 289

  Fly   233 YLYV---------------------------------------------------EKLRNLHG-K 245
            |.::                                                   |:.::... |
Human   290 YAFLSPGLGHGPHPQQAECDLPAGRIAGPCERGLERQEKLPPAPQGGAWHLRLSRERFKSEDAPK 354

  Fly   246 CFICYLASLFLGYFFLVLNVWKYSSG---FCVTAGFLGYFSVIAAFFW-------LSVISLTLWN 300
            ..:....||||.....::||...|.|   .|...|.:.::.::.||.|       |.::::.::|
Human   355 IHVALGGSLFLLNLAFLVNVGSGSKGSDAACWARGAVFHYFLLCAFTWMGLEAFHLYLLAVRVFN 419

  Fly   301 SFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQ----VVKNEKLRPRVGVGKNCWIY 361
            ::.|           :.||..:|..||:..|:...|..|:.    .:::.:.|..:.:   ||..
Human   420 TYFG-----------HYFLKLSLVGWGLPALMVIGTGSANSYGLYTIRDRENRTSLEL---CWFR 470

  Fly   362 TGDMTVMIYF--YGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTT--NRLNSDKQTYAL 422
            .|.....:|.  :|..|:..:|.:.:..|..::|         ||..:.|.  .|..:.|:...|
Human   471 EGTTMYALYITVHGYFLITFLFGMVVLALVVWKI---------FTLSRATAVKERGKNRKKVLTL 526

  Fly   423 FLRLFIIMGLSWSLEIISFL-LSKNQAWAKAFMVADYFNWSQGTVIFLLFVL 473
             |.|..::|::|.|.|.:.| ||....:|       .||..||..|...|.:
Human   527 -LGLSSLVGVTWGLAIFTPLGLSTVYIFA-------LFNSLQGVFICCWFTI 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_663308.1 Methuselah_N 26..204 CDD:429053 34/209 (16%)
7tmB3_Methuselah-like 208..486 CDD:410632 66/338 (20%)
TM helix 1 210..235 CDD:410632 8/25 (32%)
TM helix 2 244..266 CDD:410632 6/22 (27%)
TM helix 3 274..301 CDD:410632 5/33 (15%)
TM helix 4 318..338 CDD:410632 7/19 (37%)
TM helix 5 364..393 CDD:410632 5/30 (17%)
TM helix 6 415..442 CDD:410632 8/26 (31%)
TM helix 7 450..475 CDD:410632 7/24 (29%)
ADGRG3XP_005255899.1 GPS 214..255 CDD:460350 6/42 (14%)
7tmB2_GPR97 265..574 CDD:320558 66/337 (20%)
TM helix 1 267..292 CDD:320558 7/24 (29%)
TM helix 2 353..375 CDD:320558 6/21 (29%)
TM helix 3 386..413 CDD:320558 5/26 (19%)
TM helix 4 426..446 CDD:320558 7/19 (37%)
TM helix 5 475..504 CDD:320558 5/28 (18%)
TM helix 6 518..545 CDD:320558 8/27 (30%)
TM helix 7 547..572 CDD:320558 9/31 (29%)

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