Protein Alignment mthl3 and ADGRG5

DIOPT Version :9

• Sequence 1: NP_001286526.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001291305.1
• Gene: ADGRG5 / 221188
• HGNCID: 19010
• Length: 528
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 108/562 - (19%)
• Similarity: 188/562 - (33%)
• Gaps: 164/562 - (29%)

  Fly     8 FTAFLLLLLQNSNAEI--PGCDFFDTVDIS--KAPRFS------------NGSYLYEGLLIPAHL 56
            |....||.|||:..|.  ....:.:.:.:|  ::..||            |.|:....|.:....
Human     8 FLCLCLLTLQNATTETWEELLSYMENMQVSRGRSSVFSSRQLHQLEQMLLNTSFPGYNLTLQTPT 72

  Fly    57 TAEYDYKLLADDSKEKVAS------------HVRG------------CACHLRP------CIRFC 91
            .....:||..|.|...:.|            |.||            .||..||      ||.|.
Human    73 IQSLAFKLSCDFSGLSLTSATLKRVPQAGGQHARGQHAMQFPAELTRDACKTRPRELRLICIYFS 137

  Fly    92 CPQYQKMQKSKCYGDMSEDELNK---HDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYF 153
            ...:.|            ||.|.   ::..:...||.|.|  .:.::.:.:.           ::
Human   138 NTHFFK------------DENNSSLLNNYVLGAQLSHGHV--NNLRDPVNIS-----------FW 177

  Fly   154 LNHELPGNEFT--LFENGSLLRHWD-------KVELSKREYCV---QHLSFKDDSIRIAPHFCPL 206
            .|..|.|...|  .::.|:..:.|.       :.|.......:   .||::....::::|...|.
Human   178 HNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPA 242

  Fly   207 SSEHSRTW-KTVAIVISLICIILTISVYLYVEKL--------RNLHGKCFICYLASLFLGYFFLV 262
            ......|: ..|...||::..::|:.::.:..|.        .|||.       :.|.|...||:
Human   243 ELLAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHA-------SVLLLNIAFLL 300

  Fly   263 LNVWKYS--SGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLY- 324
            ...:..|  .|...||        :||....:::|...|.:..|    .|.:|...|.  ||:|
Human   301 SPAFAMSPVPGSACTA--------LAAALHYALLSCLTWMAIEG----FNLYLLLGRV--YNIYI 351

  Fly   325 ----------AWGMALLLTAITYIADQVVKNEKLRPRVGVGKN---------CWIYTGDM-TVMI 369
                      .||...||..::......|......|.....:|         ||:.:..: :|::
Human   352 RRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLV 416

  Fly   370 YFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSW 434
            ..||.  |..:||:.:.....:.:.::::.|      ...:.|...|..|   .|.|.:::|.:|
Human   417 MGYGG--LTSLFNLVVLAWALWTLRRLRERA------DAPSVRACHDTVT---VLGLTVLLGTTW 470

  Fly   435 SLEIISFLLSKNQAWAKAFMVADYF-----NWSQGTVIFLLF 471
            :|...||         ..|::...|     |...|..:||.|
Human   471 ALAFFSF---------GVFLLPQLFLFTILNSLYGFFLFLWF 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	39/236 (17%)
		7tm_4	216..436	CDD:304433	50/250 (20%)
ADGRG5	NP_001291305.1	GPS	187..232	CDD:307782	6/44 (14%)
		7tmB2_GPR114	245..518	CDD:320559	61/300 (20%)
		TM helix 1	247..272	CDD:320559	5/24 (21%)
		TM helix 2	281..303	CDD:320559	7/28 (25%)
		TM helix 3	315..342	CDD:320559	8/38 (21%)
		TM helix 4	355..375	CDD:320559	4/19 (21%)
		TM helix 5	409..438	CDD:320559	6/30 (20%)
		TM helix 6	451..478	CDD:320559	10/38 (26%)
		TM helix 7	482..507	CDD:320559	6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900