DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgrg6

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_006512741.1 Gene:Adgrg6 / 215798 MGIID:1916151 Length:1258 Species:Mus musculus


Alignment Length:342 Identity:77/342 - (22%)
Similarity:143/342 - (41%) Gaps:68/342 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 CVQHLSF-KDDSIRIAPHF--------CPLSSEH--SRTWKTVAIV------ISLICIILTISVY 233
            ||.|... ..::|.:..||        .|.|:..  .|..|.:..:      ||.|....|:..|
Mouse   830 CVAHSDLDAGETICLCSHFTHFGVL
MDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTY 894

  Fly   234 LYVEKLRNLHGKCFICYLAS--LFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVIAAFFWLSV 293
            :..||||..:....:..|:|  |||...|| |:.|..|   :|.|.....|.:|.::|.|.|:.:
Mouse   895 VAFEKLRRDYPSKILMNLSSALLFLNLIFL-LDGWVTSFGVAGLCTAVAALLHFFLLATFTWMGL 958

  Fly   294 ISLTLWNSF-SGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKN 357
            .::.::.:. ...:::::|::     |.:.:..||:..|:.:|..::.:  :|| :..:...||:
Mouse   959 EAIHMYIALVKVFNTYIHRYI-----LKFCIIGWGLPALVVSIILVSRR--QNE-VYGKESYGKD 1015

  Fly   358 -----CWIYTGDMTVMIY-----FYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNR 412
                 |||..   .|:.|     ::|.|..:   |:.||::...:|.....:..|.|.:::....
Mouse  1016 QDDEFCWIQD---PVVFYVSCAGYFGVMFFL---NVAMFIVVMVQICGRNGKRSNRTLREEVLRN 1074

  Fly   413 LNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAK---AFM-VADYFNWSQGTVIFLLF-V 472
            |.|       .:.|..::|::|.....        ||..   .|| :...||..||..||:.. .
Mouse  1075 LRS-------VVSLTFLLGMTWGFAFF--------AWGPLNIPFMYLFSIFNSLQGLFIFIFHCA 1124

  Fly   473 LRPSTLKLLKERIKGGR 489
            ::.:..|..:..:..||
Mouse  1125 MKENVQKQWRRHLCCGR 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 6/26 (23%)
7tm_4 216..436 CDD:304433 54/241 (22%)
Adgrg6XP_006512741.1 CUB 48..156 CDD:238001
LamG 188..347 CDD:389952
HRM 543..588 CDD:382965
GPS 809..854 CDD:366827 6/23 (26%)
7tm_GPCRs 869..1137 CDD:391938 66/297 (22%)
TM helix 1 871..896 CDD:341315 5/24 (21%)
TM helix 2 906..928 CDD:341315 8/22 (36%)
TM helix 3 939..966 CDD:341315 5/26 (19%)
TM helix 4 981..997 CDD:341315 3/15 (20%)
TM helix 5 1026..1049 CDD:341315 6/25 (24%)
TM helix 6 1072..1097 CDD:341315 6/39 (15%)
TM helix 7 1101..1126 CDD:341315 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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