DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and ADGRE1

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_011526096.1	Gene:	ADGRE1 / 2015	HGNCID:	3336	Length:	978	Species:	Homo sapiens

Alignment Length:	475	Identity:	113/475 - (23%)
Similarity:	168/475 - (35%)	Gaps:	165/475 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 YGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRM----------------- 151
            |.|:....:||.....||||            ||:.:.|..|.||..:
Human   524 YLDIESKVINKECSEENVTL------------DLVAKGDKMKIGCSTIEESESTETTGVAFVSFV 576

  Fly   152 ---------YFLNHELP--GNEFTLFEN----GSLLRHWDKVELS----------------KREY 185
                     :|.:|:.|  .:|..|..|    |.::....|...|                :|..
Human   577 GMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPI 641

  Fly   186 CV---------QHLSF--------------------------------KDDSIRIAPHFCPLSSE 209
            ||         :..||                                .|.|:.|..|
Human   642 CVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISH------- 699

  Fly   210 HSRTWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYL--ASLFLGYFFLVLNVWKY 268
                   |.|:|||:|::|.|:.:|....:||    ||....:|.|  .:|||.......|
Human   700 -------VGIIISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDN---- 753

  Fly   269 SSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQN-RFLSYNLYAWGMALLL 332
            ..|..:.||||.|. .:|.|||:.|.::.|: ....|...:|.|..:| :.|....:.:|:.:|:
Human   754 KMGCAIIAGFLHYL-FLACFFWMLVEAVILF-LMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLV 816

  Fly   333 TAITYIADQVVKNEKLRPR-VGVGKNCWIYTGDMTVMIY-FYGPMLLIIVFNITMFVLTAF---- 391
                     ||.:..::|: .|:...||:.|  .|..|: |.||:..:||.|..:...|.:
Human   817 ---------VVISASVQPQGYGMHNRCWLNT--ETGFIWSFLGPVCTVIVINSLLLTWTLWILRQ 870

  Fly   392 RIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVA 456
            |:..|..|....    |.|..|     |:..|.:|| |:|.||.|.|.       |....|.::|
Human   871 RLSSVNAEVSTL----KDTRLL-----TFKAFAQLF-ILGCSWVLGIF-------QIGPVAGVMA 918

  Fly   457 DYF---NWSQGTVIFLLFVL 473
            ..|   |..||..|||:..|
Human   919 YLFTIINSLQGAFIFLIHCL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	32/188 (17%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	68/232 (29%)
ADGRE1	XP_011526096.1	EGF_CA	33..62	CDD:238011
		EGF_CA	80..114	CDD:214542
		EGF_CA	132..171	CDD:214542
		EGF_CA	172..206	CDD:214542
		EGF_CA	224..260	CDD:214542
		EGF_CA	264..297	CDD:214542
		EGF_CA	313..>342	CDD:214542
		EGF_CA	360..400	CDD:284955
		GPS	638..687	CDD:197639	5/48 (10%)
		7tm_2	691..932	CDD:278432	81/288 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810