DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and lat-1

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_001366731.1 Gene:lat-1 / 174419 WormBaseID:WBGene00002251 Length:1014 Species:Caenorhabditis elegans


Alignment Length:432 Identity:89/432 - (20%)
Similarity:160/432 - (37%) Gaps:57/432 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 ELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRH- 174
            ::...|..|.:..:|.:.||:......||.:.|.:.|..|.  :.:.......|.:...|.:|| 
 Worm   430 QMTPSDVTVAIAGTDQTEVRKRRVVSRIVGASLIENGKERR--VENLTQPVRITFYHKESSVRHL 492

  Fly   175 -------WDKVELS-KREYCVQHLSFKDDSIRIA-----PHFCPLS-------SEHSRTWKT--- 216
                   |:..||. |...|  .||:.:.::...     .||..|.       :|..:|..|   
 Worm   493 SNPTCVWWNHHELKWKPSGC--KLSYHNKTMTSCDCTHLTHFAVLMDVRGHDLNEIDQTLLTLLT 555

  Fly   217 -VAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYSSGFCVTAGFL- 279
             |..:||:||::||...||...  ||...:.||.....|.|....:.     :.:|...|...| 
 Worm   556 YVGCIISIICLLLTFFAYLIFS--RNGGDRVFIHENLCLSLAIAEIT-----FLAGITRTEDSLQ 613

  Fly   280 -GYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVV 343
             |..:|...:.:||.::..|...:..:......|....|..:|.|..:....::|.:.|:.:.  
 Worm   614 CGIIAVALMYMFLSALTWMLLEGYHIHRMLTEVFPSDPRRFTYLLVGYIPPAIITLVAYLYNS-- 676

  Fly   344 KNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQK 408
                  ...|...:||:.|.:..:. :|.||...|...|..:.|.|...:  .:..:..:...:.
 Worm   677 ------DGFGTPDHCWLSTQNNFIW-FFAGPACFIFCANSLVLVKTLCTV--YQHTSGGYLPCRH 732

  Fly   409 TTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFV- 472
            ..:...|.:......|.|..::|::|...:.....|::...|..|.::   |..||..|||..| 
 Worm   733 DVDSGRSIRNWVKGSLALASLLGVTWIFGLFWVEDSRSIVMAYVFTIS---NSLQGLFIFLFHVV 794

  Fly   473 ----LRPSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPSV 510
                :|......:..|..||...:..:.:..::|...:.|.|
 Worm   795 FAEKMRKDVGHWMYRRGCGGSSNSSPNHKRHNVQRDLMSPGV 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 22/106 (21%)
7tm_4 216..436 CDD:304433 46/225 (20%)
lat-1NP_001366731.1 Gal_Lectin 51..133 CDD:396628
HormR 180..244 CDD:214468
GAIN 258..462 CDD:406802 7/31 (23%)
GPS 493..541 CDD:197639 10/49 (20%)
7tmB2_latrophilin-like_invertebrate 548..808 CDD:320556 58/280 (21%)
TM helix 1 551..575 CDD:320556 9/23 (39%)
TM helix 2 584..605 CDD:320556 4/25 (16%)
TM helix 3 615..637 CDD:320556 5/21 (24%)
TM helix 4 655..671 CDD:320556 3/15 (20%)
TM helix 5 690..713 CDD:320556 5/23 (22%)
TM helix 6 744..766 CDD:320556 4/21 (19%)
TM helix 7 771..796 CDD:320556 9/27 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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