DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgrl2

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:285 Identity:68/285 - (23%)
Similarity:121/285 - (42%) Gaps:57/285 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 TWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWK--YSSG 271
            ||  |.||:||:|:.:.|..:.:...|::    :|....|    :||:..|..::.:.|  |:..
  Rat   855 TW--VGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCI----NLFIAEFIFLIGIDKTQYTIA 913

  Fly   272 FCVTAGFLGYFSVIAAFFWLSV----ISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLL 332
            ..|.||.|.:| .:|||.|:.:    :.|.|...|....|....:     :::..|:...:..:.
  Rat   914 CPVFAGLLHFF-FLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYY-----YVAGYLFPATVVGVS 972

  Fly   333 TAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMK-- 395
            .||.|            ...|..:.||::. |...:..|.||:..||:.||...|:|..:::|  
  Rat   973 AAIDY------------KSYGTLEACWLHV-DNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS 1024

  Fly   396 --VKKEA---QNFTQQQKTTNRLNSDKQTY---ALFLR--------LFIIMGLSWSLEIISFLLS 444
              :|.::   :|....:......|:|...|   ..|::        |..::||:||..:: |:..
  Rat  1025 NTLKPDSSRLENINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGLL-FVNE 1088

  Fly   445 KNQAWAKAFMVADYFNWSQGTVIFL 469
            :....|..|..   ||..||..||:
  Rat  1089 ETVVMAYLFTA---FNAFQGLFIFI 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145
7tm_4 216..436 CDD:304433 56/247 (23%)
Adgrl2NP_599235.3 Gal_Lectin 49..129 CDD:396628
OLF 142..398 CDD:413369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:406802
GPS 788..840 CDD:197639
7tm_GPCRs 848..1129 CDD:421689 68/285 (24%)
TM helix 1 850..875 CDD:410628 9/21 (43%)
TM helix 2 884..906 CDD:410628 5/25 (20%)
TM helix 3 915..942 CDD:410628 9/27 (33%)
TM helix 4 954..974 CDD:410628 1/24 (4%)
TM helix 5 991..1020 CDD:410628 10/28 (36%)
TM helix 6 1036..1087 CDD:410628 11/51 (22%)
TM helix 7 1091..1116 CDD:410628 8/23 (35%)
Latrophilin 1128..1487 CDD:396778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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