Protein Alignment mthl3 and ADGRF3

DIOPT Version :9

• Sequence 1: NP_001286526.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001138640.1
• Gene: ADGRF3 / 165082
• HGNCID: 18989
• Length: 1079
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 111/480 - (23%)
• Similarity: 177/480 - (36%)
• Gaps: 99/480 - (20%)

  Fly    52 IPAHLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHD 116
            ||.|..|    .|:.:.::..:.|.|.....||.|               ..||....|.|....
Human   637 IPRHSLA----PLVRNGTEISITSLVLRKLDHLLP---------------SNYGQGLGDSLYATP 682

  Fly   117 PFVNV-TLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDK--- 177
            ..|.| ::..|.   |.|.:..::.......|.|...|.:|       :||:...   .|.|
Human   683 GLVLVISIMAGD---RAFSQGEVIMDFGNTDGSPHCVFWDH-------SLFQGRG---GWSKEGC 734

  Fly   178 ----VELSKREYCV-QHL-SFKDDSIRIAPHFCPLSSEHSRTWKT-VAIVISLICIILTISVYLY 235
                ...|....|: ||| :|   |:.::||..|  .|.:....| |.:..|::.:::.:.||..
Human   735 QAQVASASPTAQCLCQHLTAF---SVLMSPHTVP--EEPALALLTQVGLGASILALLVCLGVYWL 794

  Fly   236 VEK--LRN-----LHG---KCFICYLA--SLFLGYFFLVLNVWKYSSG----FCVTAGFLGYFSV 284
            |.:  :||     .|.   ....|.||  :.|||..||       |.|    .|:.|.||.:|..
Human   795 VWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFL-------SPGPRSPLCLAAAFLCHFLY 852

  Fly   285 IAAFFWLSVISLTLWNS--FSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEK 347
            :|.|||:...:|.|.:.  |..:....:|.||....|.| |...|:|.:...:.....|.::..:
Human   853 LATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGY-LCPLGLAGVTLGLYLPQGQYLREGE 916

  Fly   348 LRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVK-KEAQNFTQQQKTTN 411
                      ||: .|....:..|.||:|.||..|..:..:...::::.. .|.....::|....
Human   917 ----------CWL-DGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRPSLSEGPPAEKRQALLG 970

  Fly   412 RLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLRPS 476
            .:.:       .|.|..|.||:|.|.:.:.|...:......|.:   .|..||..|.|...|..
Human   971 VIKA-------LLILTPIFGLTWGLGLATLLEEVSTVPHYIFTI---LNTLQGVFILLFGCLMD- 1024

  Fly   477 TLKLLKERIKGGRDEAGASDEHISL 501
              :.::|.::.....|.|....|||
Human  1025 --RKIQEALRKRFCRAQAPSSTISL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	36/161 (22%)
		7tm_4	216..436	CDD:304433	58/239 (24%)
ADGRF3	NP_001138640.1	HRM	431..477	CDD:280888
		GPS	713..758	CDD:280071	14/57 (25%)
		7tm_4	770..1016	CDD:304433	64/274 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810