DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl3 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	415	Identity:	101/415 - (24%)
Similarity:	164/415 - (39%)	Gaps:	125/415 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 VVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNE--------FTLFENGSLLRHWD----KVEL 180
            ||.....:|:.:| :||.   |.:..|.| :.||:        |..|||.:.|..|:    ||:.
Human  2649 VVSASISDDMFIQ-NLAD---PVVITLQH-IGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKE 2708

  Fly   181 SKREYCV---QHLSFKDDSIRIAPHFCPL-----SSEHSRTWKTVAIV------ISLICIILTIS 231
            :...|.:   .||:          ||..|     |:..|...:.:|::      ||.|.:.:.:.
Human  2709 TNVNYTICQCDHLT----------HFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVV 2763

  Fly   232 VYLYVEKLRNLHGKCFICYL--ASLFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVIAAFFWL 291
            .|:...|||..:....:..|  |.|.|...||: |.|..|   .|.|:||....::.::.:|.|:
Human  2764 TYIAFHKLRKDYPAKILINLCTALLMLNLVFLI-NSWLSSFQKVGVCITAAVALHYFLLVSFTWM 2827

  Fly   292 SV----ISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRV 352
            .:    :.|.|...|       |.::| |..|.:.|..||:..::.|||               |
Human  2828 GLEAVHMYLALVKVF-------NIYIP-NYILKFCLVGWGIPAIMVAIT---------------V 2869

  Fly   353 GVGKN-----------CWIYTGD---MTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNF 403
            .|.|:           |||....   ::|:.||    .||.:.|::||.....::..||
Human  2870 SVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYF----CLIFLMNLSMFCTVLVQLNSVK------ 2924

  Fly   404 TQQQKTTNR--LNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAK-----AFMVADYFNW 461
            :|.|||..:  |:..|.|    :.|..::||:|.....        ||..     .::.| .||.
Human  2925 SQIQKTRRKMILHDLKGT----MSLTFLLGLTWGFAFF--------AWGPMRNFFLYLFA-IFNT 2976

  Fly   462 SQGTVIFLLFVLRPSTLKLLKERIK 486
            .||..||:...       ::||.::
Human  2977 LQGFFIFVFHC-------VMKESVR 2994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	23/90 (26%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	63/250 (25%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071	13/52 (25%)
		7tm_2	2743..2982	CDD:278432	70/285 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810