DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgre1

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_001342651.1 Gene:Adgre1 / 13733 MGIID:106912 Length:931 Species:Mus musculus


Alignment Length:568 Identity:122/568 - (21%)
Similarity:202/568 - (35%) Gaps:190/568 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DISKAPRFSNGSYLYE--------GLLIPA-----HLTAEY---DYKLLADDSKEKVASHV--RG 79
            ::||....:.|:.|.|        .||||:     .:..||   :.|::.::.||..:.::  ||
Mouse   443 ELSKEETSTLGTILLETVESTMLAALLIPSGNASQMIQTEYLDIESKVINEECKENESINLAARG 507

  Fly    80 CACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLA 144
                                          |::|.....:..::|.|:                 
Mouse   508 ------------------------------DKMNVGCFIIKESVSTGA----------------- 525

  Fly   145 KPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKRE------------------YCVQHLS 191
             ||...:.|.:.|...|| ..||:|...|   |:.::.|.                  |.:||:.
Mouse   526 -PGVAFVSFAHMESVLNE-RFFEDGQSFR---KLRMNSRVVGGTVTGEKKEDFSKPIIYTLQHIQ 585

  Fly   192 FKDDSI--------------RIAPHFCPLSSEHSRTWKT-------------------------- 216
            .|..|.              |..|..|.: .|.|.|...                          
Mouse   586 PKQKSERPICVSWNTDVEDGRWTPSGCEI-VEASETHTVCSCNRMANLAIIMASGELTMEFSLYI 649

  Fly   217 ---VAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWK--YSSGF 272
               |..||||:|:.|.|:.:|....::|    :|....:|    |||.....:..:.|  ..:..
Mouse   650 ISHVGTVISLVCLALAIATFLLCRAVQNHNTYMHLHLCVC----LFLAKILFLTGIDKTDNQTAC 710

  Fly   273 CVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQN-RFLSYNLYAWGMALLLTAIT 336
            .:.||||.|. .:|.|||:.|.::.|: ....|...:|.|..:| :.|....:.:|:.:|:    
Mouse   711 AIIAGFLHYL-FLACFFWMLVEAVMLF-LMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVLV---- 769

  Fly   337 YIADQVVKNEKLRPR-VGVGKNCWIYTGDMTVMIY-FYGPMLLIIVFNITMFVLTAFRIMKVKKE 399
                 |:.:..::|| .|:...||:.|  .|..|: |.||:.:||..|..:...|.:.:.:....
Mouse   770 -----VIISASVQPRGYGMHNRCWLNT--ETGFIWSFLGPVCMIITINSVLLAWTLWVLRQKLCS 827

  Fly   400 AQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYF---NW 461
            ..:...:.|.|..|     |:....::| |:|.||.|.|.       |....|.::|..|   |.
Mouse   828 VSSEVSKLKDTRLL-----TFKAIAQIF-ILGCSWVLGIF-------QIGPLASIMAYLFTIINS 879

  Fly   462 SQGTVIFLLFVLRPSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPS 509
            .||..|||:..       ||..:::         ||:..|...|.|.|
Mouse   880 LQGAFIFLIHC-------LLNRQVR---------DEYKKLLTRKTDLS 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 39/220 (18%)
7tm_4 216..436 CDD:304433 59/257 (23%)
Adgre1NP_001342651.1 EGF_CA 33..63 CDD:238011
EGF_CA 81..115 CDD:214542
EGF_CA 133..172 CDD:214542
EGF_CA 173..>203 CDD:214542
EGF_CA 222..258 CDD:238011
EGF_CA 272..>301 CDD:214542
EGF_CA 319..352 CDD:214542
Cell attachment site. /evidence=ECO:0000255 506..508 2/31 (6%)
GPS 591..640 CDD:197639 6/49 (12%)
7tmB2_EMR 644..906 CDD:320555 76/307 (25%)
TM helix 1 646..671 CDD:320555 8/24 (33%)
TM helix 2 680..702 CDD:320555 5/25 (20%)
TM helix 3 711..738 CDD:320555 11/28 (39%)
TM helix 4 755..775 CDD:320555 4/28 (14%)
TM helix 5 792..815 CDD:320555 8/22 (36%)
TM helix 6 839..864 CDD:320555 10/37 (27%)
TM helix 7 868..893 CDD:320555 9/31 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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