Protein Alignment mthl3 and LOC1276880

DIOPT Version :10

• Sequence 1: NP_663308.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_061496511.1
• Gene: LOC1276880 / 1276880
• VectorBaseID: AGAMI1_002326
• Length: 1064
• Species: Anopheles gambiae
• Alignment Length: 511
• Identity: 169/511 - (33%)
• Similarity: 277/511 - (54%)
• Gaps: 50/511 - (9%)

  Fly     2 RIVIGSFTAFLLLL--LQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLI--PAHLTAEYDY 62
            |||     |.||:|  :::|...:| |||.|:|:|:...|..|....:.|::.  ..:...:|||
Mosquito     5 RIV-----ACLLVLFGVRSSVCSLP-CDFIDSVNITDGERLPNDEIRHNGVIYNKTYYRVIDYDY 63

  Fly    63 KLLADDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDP-FVNVTLSDG 126
            :..|  :|..|.::||||.|.:|.|:|.||.:::.:.| :|  ..::|.|    | .|||:.::.
Mosquito    64 QDFA--TKRYVPNYVRGCLCAVRICVRLCCGEHEYLGK-RC--THTDDYL----PILVNVSATEA 119

  Fly   127 SVVRRHFKEDLIVQSDLAKPGCPRMY-FLNHELPGNEFTLFENGSLLRHWDKVELSKREYCV--- 187
            ..:|.|.....:    ..|| |.::| .|..|.|.:|:::..||||:.. |::.:.:.:||:
Mosquito   120 VDLRNHSLYGFL----YGKP-CEQVYELLPEESPADEWSIARNGSLIIA-DELLIQRNQYCLAPR 178

  Fly   188 QHLSFKDDSIRIAPHFCPLSSEHSR-TWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYL 251
            |:..|....:      |..::|..: ....|.:::|:..::||..||..:..|||:|||..:||:
Mosquito   179 QNNGFASGLV------CFTTNEEFKYNLYPVGMLLSVPFLLLTFFVYACIPDLRNMHGKSLMCYV 237

  Fly   252 ASLFLGYFFL---VLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFL 313
            ..|.:||..|   .|.|:...|..||.:|::.|||.:.:||||:|:|..::.:|.|.:.  .|..
Mosquito   238 LGLSVGYTVLSMVQLRVFPGLSASCVISGYIVYFSFMVSFFWLNVMSFDIYWTFKGVTG--VRSS 300

  Fly   314 PQNRFLSYNLYAWGMALLLTAITYIADQV-VKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLL 377
            ...:||.|:|||||..:||.|...|||.. :....|||:.|..: |......:...:|.|.|:|:
Mosquito   301 ETKKFLLYSLYAWGCPILLVATAIIADYTDILPIYLRPQFGTTR-CLFVENKLIEFLYLYMPLLI 364

  Fly   378 IIVFNITMFVLTAFRIMKVKKEAQNFTQ-QQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISF 441
            ::..|:..||:||.||.|::.|.....: ..|...:|::|:..:.|:|||||:||::|||||||:
Mosquito   365 LVFMNVVFFVITALRIYKIQCETSVVRRGDSKRHTKLDNDRDRFGLYLRLFIVMGVTWSLEIISW 429

  Fly   442 LLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLRPSTLKLLKER--IKGGRDEAGAS 495
            .:. |.||  .|.|:|..|..||.:||.||||:....:|:.::  |:..|.|...|
Mosquito   430 AVD-NNAW--IFYVSDVCNCIQGFLIFALFVLKQKIKRLIYKKFGIREIRQEQKTS 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_663308.1	Methuselah_N	26..204	CDD:429053	52/184 (28%)
		7tmB3_Methuselah-like	208..486	CDD:410632	103/285 (36%)
		TM helix 1	210..235	CDD:410632	6/25 (24%)
		TM helix 2	244..266	CDD:410632	9/24 (38%)
		TM helix 3	274..301	CDD:410632	11/26 (42%)
		TM helix 4	318..338	CDD:410632	11/19 (58%)
		TM helix 5	364..393	CDD:410632	9/28 (32%)
		TM helix 6	415..442	CDD:410632	16/26 (62%)
		TM helix 7	450..475	CDD:410632	12/24 (50%)
LOC1276880	XP_061496511.1	None