Protein Alignment mthl3 and LOC1276878

DIOPT Version :10

• Sequence 1: NP_663308.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_061505534.1
• Gene: LOC1276878 / 1276878
• VectorBaseID: AGAMI1_007727
• Length: 511
• Species: Anopheles gambiae
• Alignment Length: 551
• Identity: 146/551 - (26%)
• Similarity: 253/551 - (45%)
• Gaps: 93/551 - (16%)

  Fly     8 FTAFLLLLLQNSNAEIP----------GCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDY 62
            |.|.::|::..:|.||.          .|...:.:|:::......||..:.|.:.|:.     :|
Mosquito     7 FYAEMILIIYCANIEIKIVYGDQMDPFDCPTAERIDLTEGVPDLQGSIRFAGNVYPSE-----NY 66

  Fly    63 KLLADDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGS 127
            ...:|.      :|...|.|.:|.|:..||....:.:..:....::...||:      .:.||
Mosquito    67 TQRSDH------NHRYSCVCAVRKCVYVCCYHINRTECEQSALPLNRTSLNR------ASWSD-- 117

  Fly   128 VVRRHFKEDLIVQSDLAK-----------PGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELS 181
                   .||:.:.||.:           |....|...:.::.|:|..|..:|| ..:..||..|
Mosquito   118 -------VDLLEEVDLRESSEYWLIYATPPAWSSMPGYSLQIAGHEGELINDGS-FAYGAKVYAS 174

  Fly   182 KREYCVQHLSFKDDSIRIAPHFCPL-SSEHSRT--WKTVAIVISLICIILTISVYLYVEKLRNLH 243
             |.||:..   .:||   .||...: :.||...  |.::.::||:..:|.|:.||..:..|||:.
Mosquito   175 -RTYCINP---AEDS---TPHVWIMETDEHLEVHRWHSLGMIISIPFLIATLIVYALIPDLRNIP 232

  Fly   244 GKCFICYLASLFLGYFFLVL---NVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGN 305
            ||..:||:..|.:.|..|:|   :|:..|..:|...|:..||||:::||||::::..::.:|.|.
Mosquito   233 GKSLMCYVLMLMVSYLALILIKRSVFDGSPDWCTGIGYAYYFSVMSSFFWLNLMAFDIFWTFGGR 297

  Fly   306 SSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQV-VKNEKLRPRVGVGKNCWIYTGDMTV-M 368
            .   .|...|.:||.|..|.:|..|:..||..:||.. :....|||..|.|: | ::.|:..| .
Mosquito   298 R---RRTTDQGKFLLYCCYGFGSPLIFLAIALVADHTELMYTSLRPGFGDGQ-C-LFKGEQFVSF 357

  Fly   369 IYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQ-----QQKTTNRLNSDKQTYALFLRLFI 428
            :|.|.|::|::..|:..|:.||.:|..:::......|     ..|.||    ::..|.|::|||:
Mosquito   358 LYLYLPLVLLVSANLFFFISTAAKINSIERTTAAALQGESGRHSKYTN----ERNRYGLYVRLFV 418

  Fly   429 IMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLRPSTLKLLKERIKG----GR 489
            :||::|:.|.|:: .::.|.|  .....|..|...|..||.|||.:....|||::|:.|    .|
Mosquito   419 VMGVTWTFEFITW-FAEAQNW--LVYATDVCNCISGVFIFFLFVWKRKVWKLLQQRLSGKEVQKR 480

  Fly   490 DEA-----GASDEHIS----LQNTKIDPSVF 511
            ::|     |.....::    |...|:|.|.|
Mosquito   481 NQALFSVSGTRTTSLAPGRKLSTLKMDTSSF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_663308.1	Methuselah_N	26..204	CDD:429053	40/188 (21%)
		7tmB3_Methuselah-like	208..486	CDD:410632	91/289 (31%)
		TM helix 1	210..235	CDD:410632	8/26 (31%)
		TM helix 2	244..266	CDD:410632	8/24 (33%)
		TM helix 3	274..301	CDD:410632	9/26 (35%)
		TM helix 4	318..338	CDD:410632	8/19 (42%)
		TM helix 5	364..393	CDD:410632	9/29 (31%)
		TM helix 6	415..442	CDD:410632	10/26 (38%)
		TM helix 7	450..475	CDD:410632	8/24 (33%)
LOC1276878	XP_061505534.1	None