DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and adgre13

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_021327151.1	Gene:	adgre13 / 100538238	ZFINID:	ZDB-GENE-150505-3	Length:	303	Species:	Danio rerio

Alignment Length:	263	Identity:	59/263 - (22%)
Similarity:	112/263 - (42%)	Gaps:	33/263 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 VAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGY-FFLV----LNVWKYSSGFCVTA 276
            |.:::.|:...|.:..:.:.:....::....|....||.|.: .||:    |::.:.....|...
Zfish    21 VCVIVGLLFFSLALLTFAFCQWGPGVNNVARINICISLLLAHLLFLLTQQFLSLIRRQQMLCEVI 85

  Fly   277 GFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLY--AWGMALLLTAITYIA 339
            ..|.:|..::.|.|:.:.::.|:.....    |::...|.|.:..|::  ..|.|:.|..:...|
Zfish    86 SGLLHFLFLSGFVWMFIEAVLLFICVKN----LSQISSQKRNVLRNIFLCVIGYAVALVVVGISA 146

  Fly   340 DQVVKNEKLRPRVGVG-KNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNF 403
            ..|.|        |.| :.|||.. |...:..|.||:.:|:..|:.:|:.....:    |.|  |
Zfish   147 AVVPK--------GYGSEKCWIKM-DKGFIWSFLGPVTVILALNVILFIGIGVSL----KSA--F 196

  Fly   404 TQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIF 468
            .:.....::||..|......|..|:::|.||   |:.|..:.::.....|::   .|..|||.||
Zfish   197 KKLNADVSQLNQTKIIMFKTLAQFVVLGCSW---ILGFFTNSSKVLEILFLI---LNSQQGTFIF 255

  Fly   469 LLF 471
            |::
Zfish   256 LIY 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	49/226 (22%)
adgre13	XP_021327151.1	7tm_GPCRs	12..274	CDD:333717	59/263 (22%)
		TM helix 1	15..39	CDD:320095	3/17 (18%)
		TM helix 2	48..69	CDD:320095	6/20 (30%)
		TM helix 3	83..105	CDD:320095	4/21 (19%)
		TM helix 4	129..145	CDD:320095	3/15 (20%)
		TM helix 5	163..186	CDD:320095	6/22 (27%)
		TM helix 6	210..233	CDD:320095	8/25 (32%)
		TM helix 7	237..262	CDD:320095	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010