DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl3 and adgre5b.1

DIOPT Version :10

Sequence 1:NP_663308.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_005171094.1 Gene:adgre5b.1 / 100536657 ZFINID:ZDB-GENE-130116-3 Length:761 Species:Danio rerio


Alignment Length:511 Identity:100/511 - (19%)
Similarity:190/511 - (37%) Gaps:134/511 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 IRFCCPQYQ----KMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGC 148
            :|..|||.:    :|:....|.:::... |:..|..:|.||.||.:.....|.::.:|   .||.
Zfish   286 MRLICPQLKEPVMRMETHNTYAEVAVTR-NQTPPSGSVILSTGSALFNTSWETVVGKS---YPGF 346

  Fly   149 PRMYFLNHELPGNEFTLFENGS---------------------LLRHWDKVELSKREYCV-QHLS 191
            ..:..::::...:...||.|.|                     ::.:.|...||:....: .|:.
Zfish   347 AFVSLVSYKDMNSSSNLFRNVSRKKSDMEENVTHKLNSKVVTVVVSNPDTKHLSEPVSLIFTHVE 411

  Fly   192 FKDDSIRIAPHFCPLSSEHSRTWK----------------------------------------- 215
            .:.:|..:| :.|...:|..|.|.                                         
Zfish   412 ERAESKAVA-YNCVYWAESERAWSRQGCERAWSNSTHTECSCSHLSSFAVLMSLYPVQDTFELVL 475

  Fly   216 --TVAIVISLICIILTISVYLY---VEKLRN-LHGKCFIC-YLASLFLGYFFLVLNVWKYSSGFC 273
              .|.:|:||:|:.|.|..:.:   ::..|| :|....:| ::|.|   .|...::.........
Zfish   476 ITRVGLVLSLLCLFLCILTFRFCRSIQGTRNSIHLHLSVCLFIADL---VFLCGISSTHNQVACA 537

  Fly   274 VTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYI 338
            :.||.|.:| .::||.|:.:..:.|:...      :..|....:.|......:|:.|::.:|:.|
Zfish   538 IVAGLLHFF-FLSAFCWMLLEGVQLYRMV------VLVFHTTLKHLYMYAVGYGVPLVIVSISAI 595

  Fly   339 ADQVVKNEKLRPR-VGVGKNCWIYTGDMTVMIY-----FYGPMLLIIVFNITMFVLTAFRIMKVK 397
            |         .|: .|..::||:      .:.|     |..|:.|||..|..:||:|.:::    
Zfish   596 A---------FPKGYGTDRHCWL------SLKYDFIWSFLAPVCLIIGLNSLVFVITVWKL---- 641

  Fly   398 KEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADY---- 458
              |:.|:......::|.:.:......:....::|..|...  |||.     :.|...||.|    
Zfish   642 --AEKFSSLNPDLSKLRTIRGFTVTAVAQLCVLGGMWIFG--SFLF-----YEKVTQVALYLFVI 697

  Fly   459 FNWSQGTVIFLLFVL-----RPSTLKLLKE--RIKGGRDEAGASDEHISLQNTKID 507
            .|..||.:||::..|     |....||:..  .:|..:....::..|.|.|..:.|
Zfish   698 LNSLQGALIFIMHCLLSRQVREEYCKLITRICSLKKKKYSEFSTSNHSSQQPLRSD 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_663308.1 Methuselah_N 26..204 CDD:429053 27/141 (19%)
7tmB3_Methuselah-like 208..486 CDD:410632 67/342 (20%)
TM helix 1 210..235 CDD:410632 9/67 (13%)
TM helix 2 244..266 CDD:410632 4/22 (18%)
TM helix 3 274..301 CDD:410632 8/26 (31%)
TM helix 4 318..338 CDD:410632 4/19 (21%)
TM helix 5 364..393 CDD:410632 10/33 (30%)
TM helix 6 415..442 CDD:410632 3/26 (12%)
TM helix 7 450..475 CDD:410632 10/33 (30%)
adgre5b.1XP_005171094.1 EGF_CA 34..67 CDD:214542
EGF_CA 81..112 CDD:429571
EGF_CA 124..153 CDD:214542
EGF_CA 162..193 CDD:429571
GAIN 227..392 CDD:465137 21/109 (19%)
GPS 422..467 CDD:197639 4/44 (9%)
7tm_GPCRs 470..730 CDD:475119 64/297 (22%)
TM helix 1 473..497 CDD:410628 7/23 (30%)
TM helix 2 506..527 CDD:410628 6/23 (26%)
TM helix 3 537..559 CDD:410628 7/22 (32%)
TM helix 4 577..593 CDD:410628 2/15 (13%)
TM helix 5 612..635 CDD:410628 7/22 (32%)
TM helix 6 662..684 CDD:410628 5/28 (18%)
TM helix 7 689..714 CDD:410628 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.