Protein Alignment mthl4 and ADGRE5

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_510966.1
• Gene: ADGRE5 / 976
• HGNCID: 1711
• Length: 835
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 120/604 - (19%)
• Similarity: 210/604 - (34%)
• Gaps: 182/604 - (30%)

  Fly    25 FFDTV-DISKAPRFSNGSYLYEGL--LIPAHLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIR 86
            |||.| |:.:..:.|:.....:.:  |:...:.|..|.:.||...:..:|:.:   ..:|...:|
Human   278 FFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQL---LSNLEDIMR 339

  Fly    87 FCCPQYQKMQKSKCYGDMSEDEL-----NKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCP 146
            .......|...:  |...|..||     .:.|.  |||:...|.   ..|.:..|.:....||..
Human   340 ILAKSLPKGPFT--YISPSNTELTLMIQERGDK--NVTMGQSSA---RMKLNWAVAAGAEDPGPA 397

  Fly   147 RMYFLNHELPGNEFTLFENGSLLRHWDK--------------VELSKRE---------------- 181
            ....|:.:   |..||..|.||..|..|              |:|.:..
Human   398 VAGILSIQ---NMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELN 459

  Fly   182 ----YCVQHLS---------------------------FKDDSIR---IAPHFCP-LSSEHSRT- 210
                :...||.                           :|.||.|   .|...|. |.|::..|
Human   460 SPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTT 524

  Fly   211 --------------------WK-----TVAIVISLICIILTISVYLYVEKLR----NLHGKCFIC 246
                                ||     .|.:.:||.|::|.|..:|.|..::    .:|....||
Human   525 CQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCIC 589

  Fly   247 YLASLFLGYFFLVLNVWKYSSGF---C-VTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLH 307
                ||:|....:..:.......   | :.||.| ::..:|||.|:|:.|:.|
Human   590 ----LFVGSTIFLAGIENEGGQVGLRCRLVAGLL-HYCFLAAFCWMSLEGLEL------------ 637

  Fly   308 RLLPENPFRAYN-------LYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVM 365
            ..|....|:...       |..:|:||::..::..   :......|||.     ||: ..:...:
Human   638 YFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAA---IYSKGYGRPRY-----CWL-DFEQGFL 693

  Fly   366 IYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSW 430
            ..|.||:..:|..|.::||.:   ::.:.:....:....:..::.....:.|| .:|| |:|.:|
Human   694 WSFLGPVTFIILCNAVIFVTT---VWKLTQKFSEINPDMKKLKKARALTITAI-AQLF-LLGCTW 753

  Fly   431 SFEILSFLLTKQQAWARALMVADYF---NWSQGTIIFVLFILKPSILK-------LIIAGGRQ-- 483
            .|.:..|       ..|:|::...|   |..||..:::|..|....::       .::|||.:
Human   754 VFGLFIF-------DDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYS 811

  Fly   484 ----NLPGSHHNSRSKAAR 498
                ...|:.|| :::|.|
Human   812 EFTSTTSGTGHN-QTRALR 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	46/247 (19%)
		7tm_4	213..>385	CDD:304433	42/186 (23%)
ADGRE5	NP_510966.1	EGF_CA	64..99	CDD:284955
		EGF_CA	116..>148	CDD:214542
		EGF_CA	160..207	CDD:284955
		EGF_CA	209..243	CDD:284955
		GPS	493..536	CDD:280071	9/42 (21%)
		7tm_2	544..782	CDD:278432	60/275 (22%)
		ProP	608..>785	CDD:223553	44/210 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..835		5/17 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810