Protein Alignment mthl4 and ADGRG1

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_005256294.1
• Gene: ADGRG1 / 9289
• HGNCID: 4512
• Length: 698
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 86/406 - (21%)
• Similarity: 147/406 - (36%)
• Gaps: 111/406 - (27%)

  Fly   146 PRMYFLNHELPGNEFTL-----FENGSLLR--HWDKV--ELSKRE-----YCVQHLSF------- 189
            |.:....|:|.....||     .|:.:|..  ||...  |..:||     :| .||::
Human   333 PVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFC-NHLTYFAVLMVS 396

  Fly   190 --KDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYL--------------YVEKLR- 237
              :.|::.  .|:..|.|       .|..|:|.:..::||:.||              |..|:.
Human   397 SVEVDAVH--KHYLSLLS-------YVGCVVSALACLVTIAAYLCSRVPLPCRRKPRDYTIKVHM 452

  Fly   238 NLHGKCFICYLASLFLGYFFLV---LNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKF 299
            ||       .||...|...||:   :.:....:|...:|.|| :||::....|:.:.|.:
Human   453 NL-------LLAVFLLDTSFLLSEPVALTGSEAGCRASAIFL-HFSLLTCLSWMGLEGYN----- 504

  Fly   300 SLASNCLHRLLPENPFRAY--------NLYAWGIPLIMTAITYTADQ------VVKNEKLRPRVG 350
                  |:||:.| .|..|        :...||.|:.:..:....|.      ::...:....|.
Human   505 ------LYRLVVE-VFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVI 562

  Fly   351 VGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQM 415
            ....||| ...:...|...|...|:..||:.|.....:.|..::.      |.|:.:..:.
Human   563 YPSMCWI-RDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRP------HTQKWSHVLT---- 616

  Fly   416 FAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADYFN---WSQGTIIFVLFILKPSILKLI 477
               .|.|.:::||.|:....||.....|     |:|...|:   ..||.:||:.:    ..::|.
Human   617 ---LLGLSLVLGLPWALIFFSFASGTFQ-----LVVLYLFSIITSFQGFLIFIWY----WSMRLQ 669

  Fly   478 IAGGRQNLPGSHHNSR 493
            ..||...|..:..::|
Human   670 ARGGPSPLKSNSDSAR 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	17/77 (22%)
		7tm_4	213..>385	CDD:304433	44/203 (22%)
ADGRG1	XP_005256294.1	GPS	349..393	CDD:280071	11/44 (25%)
		7tm_4	408..659	CDD:304433	62/296 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810