DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and ADGRG7

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_116176.2	Gene:	ADGRG7 / 84873	HGNCID:	19241	Length:	797	Species:	Homo sapiens

Alignment Length:	356	Identity:	73/356 - (20%)
Similarity:	129/356 - (36%)	Gaps:	123/356 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 SRTWKTVAIVISLICIILTISVYLYVEKLRN-----------LHGKCF----------------I 245
            |.||     |:..:||.:.|...|:|..:.|           ::...|                :
Human   466 SVTW-----VLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPM 525

  Fly   246 CYLASLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLL 310
            |...:..|.||.||...|.     .::|..|.|..:...                       :.|
Human   526 CTAIAALLHYFLLVTFTWN-----ALSAAQLYYLLIRTM-----------------------KPL 562

  Fly   311 PENPFRAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGV-----GKN------------CWIY 358
            |.:.....:|..||:|.|:.|||               |||     |.|            ||:.
Human   563 PRHFILFISLIGWGVPAIVVAIT---------------VGVIYSQNGNNPQWELDYRQEKICWLA 612

  Fly   359 TGDMTVMI------YFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFA 417
            ..:...:|      .|..|:.:::..|::||:..:|.:  :.||.:.|.    :.::::..:...
Human   613 IPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKV--LWKNNQNLT----STKKVSSMKKIV 671

  Fly   418 IFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADY----FNWSQGTIIFVLFILKPSILK--- 475
            ..|.:.::.|::|   ||::|:.......|  :|..|    ||.:||..||:|:.::..:.:
Human   672 STLSVAVVFGITW---ILAYLMLVNDDSIR--IVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEA 731

  Fly   476 ------LIIAGGRQNLPGSHHNSRSKAARYN 500
                  |...|.|::|| |....|.:...||
Human   732 SKVLMLLSSIGRRKSLP-SVTRPRLRVKMYN 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	41/221 (19%)
ADGRG7	NP_116176.2	GPS	383..422	CDD:197639
		7tmB2_GPR128	431..737	CDD:320385	64/329 (19%)
		TM helix 1	433..458	CDD:320385
		TM helix 2	468..490	CDD:320385	8/26 (31%)
		TM helix 3	527..554	CDD:320385	8/31 (26%)
		TM helix 4	567..587	CDD:320385	8/34 (24%)
		TM helix 5	621..651	CDD:320385	6/31 (19%)
		TM helix 6	665..692	CDD:320385	6/29 (21%)
		TM helix 7	699..724	CDD:320385	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810