DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and adgrg3

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021333690.1	Gene:	adgrg3 / 799479	ZFINID:	ZDB-GENE-140106-110	Length:	420	Species:	Danio rerio

Alignment Length:	435	Identity:	100/435 - (22%)
Similarity:	163/435 - (37%)	Gaps:	120/435 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 QKSKCYGDM-----------SEDELNKHDP------FVNVTLSDGSVVRRHFKEDLIVQSDLAKP 143
            :||.|..::           ..::||..||      .:.|.|....|            ::|::|
Zfish     9 RKSVCLNNVVSSLSLVVLAQEGNDLNGSDPVLLKQSVLGVWLGTTEV------------NNLSQP 61

  Fly   144 GCPRMYFLN-HELPGNEFTLF----ENGSLLRHWD----KVELSKREY-C-VQHLSFKDDSIRIA 197
              .::.|.| |....|...::    :||.  .:|.    |..:...:: | ..||||  .::.|:
Zfish    62 --VQLKFRNTHNQTENGICVYWHLEKNGG--GNWSTDGCKTNIDNGDFVCSCNHLSF--FAVLIS 120

  Fly   198 PHFCPLSSE--HSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLAS-LFLGYFFLV 259
            |.. |..|.  |......|...:|:....|.|.::|...|.:..|.......|:| |||.:...:
Zfish   121 PQI-PEKSHIVHLNYISYVGSALSIAFTSLVIVLFLCQRKKQCEHSLVIHVQLSSCLFLLHISFL 184

  Fly   260 LNVW----KYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNL 320
            .:||    ..|...|.|.|.|.::.::|.|.|.::.|.|           |:.||    .|.:|:
Zfish   185 CSVWFSGHSDSDSVCQTIGLLLHWCLLATFTWTAIEGFH-----------LYLLL----VRVFNI 234

  Fly   321 Y-----------AWGIPLI------MTAI-----TYTADQVVKNEKLRPRVGVGKNCWIYTGDMT 363
            |           .||:|.:      ||.:     .||..:......|         ||: |.:..
Zfish   235 YIKRYMLKLSLMGWGVPTVTAMICGMTKVYGKYTLYTDQENSTATSL---------CWV-TTNTV 289

  Fly   364 VMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQM----FAIFLRLFI 424
            :.|...|.:.|::.||:.|..:..:.:..::          |.|.||:.|:.    ....|.|..
Zfish   290 IYITVNGYLGLVMLFNMAMLAVVVVKMRQLR----------QQNVQIDHQKRAWKDCVSLLGLCF 344

  Fly   425 LMGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFIL 469
            ::|:.|.   |:| .|.......||.|....|..||..|| |:||
Zfish   345 VLGVPWG---LAF-STHGPLSLPALYVFTILNSFQGVFIF-LWIL 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	27/132 (20%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	47/198 (24%)
adgrg3	XP_021333690.1	GPS	77..118	CDD:307782	9/44 (20%)
		7tm_GPCRs	132..393	CDD:333717	70/293 (24%)
		TM helix 1	132..156	CDD:320095	4/23 (17%)
		TM helix 2	166..187	CDD:320095	5/20 (25%)
		TM helix 3	200..222	CDD:320095	6/21 (29%)
		TM helix 4	242..258	CDD:320095	3/15 (20%)
		TM helix 5	287..310	CDD:320095	6/22 (27%)
		TM helix 6	333..358	CDD:320095	7/28 (25%)
		TM helix 7	362..387	CDD:320095	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810