DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_001070157.3	Gene:	Adgrd1 / 689257	RGDID:	1594795	Length:	903	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	93/431 - (21%)
Similarity:	160/431 - (37%)	Gaps:	106/431 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PFVNVTLSDGSVVRRHFKEDLIVQSDL-AKPGCPRMY----FLNHELPGNEFTLFENGSLLRHWD 173
            |.::..||...::..|.:..|..:..: |.....|::    |||          |.:|..:  |.
  Rat   500 PTLSQNLSGSPLITVHLRHKLTQKQYVDATNESNRLFLYCAFLN----------FSSGEGV--WS 552

  Fly   174 KVELSKRE--------YCVQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIV---ISLICI---I 224
            ....:..|        :|. ||:.....:::.|  ..|:..|.....:::.|   :|::|:   :
  Rat   553 SQGCALTEGNLTYSVCHCT-HLTNFAILMQVVP--LKLTLGHQVALSSISYVGCSLSVLCLAATL 614

  Fly   225 LTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWKYSSGF--CVTAGFLGYFSVMA 283
            :|.:|...|..:||    :|.......|.:.     .|:|..:....|.  |.....|.::..:.
  Rat   615 VTFAVLSSVSTIRNQRYHIHANLSFAVLVAQ-----VLLLISFSMEPGTVPCQVLAVLLHYFFLT 674

  Fly   284 AFFWLSVIGIHLR---IKFSLASNCLHRLLPENPFRAYNLY----AWGIPLIMTAITYTADQVVK 341
            ||.|:.|.|:||.   ||...:.:..|            ||    .||.||::..|:.::..
  Rat   675 AFAWMLVEGLHLYSMVIKVFGSEDSKH------------LYYYGIGWGCPLLICIISVSSSM--- 724

  Fly   342 NEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQT 406
                 ...|.|.:||:......:.. |.||.||:|..||::.|.....|.:|..: ...:|
  Rat   725 -----DSYGTGDSCWLSVESGAIWA-FVGPALLVIVVNIVILVAVTRVISHISTD-SYKIH---- 778

  Fly   407 NQQINDQQMFAIFLR----LFILMGLSWSFEILSFLLTKQQAWARALMVADYF---NWSQGTIIF 464
                .|...|.:..:    |..::|.||.|.:|:       ...|||:....|   |.|||..||
  Rat   779 ----GDPSAFKLTAKAVAVLLPILGTSWVFGVLA-------VSDRALVFQYMFAILNSSQGLFIF 832

  Fly   465 VLFILKPSILKLIIAGGRQNLPGSHHNSRSKAARYNSTHTA 505
            :...|..|.::...          .|..:..:...:|.|||
  Rat   833 LFHCLLNSEVRAAF----------KHKMKVWSLTSSSAHTA 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	18/99 (18%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	44/190 (23%)
Adgrd1	XP_001070157.3	LamG	<173..273	CDD:304605
		GPS	539..579	CDD:280071	10/52 (19%)
		7tm_4	595..831	CDD:304433	64/277 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810