DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and ADGRL4

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_071442.2	Gene:	ADGRL4 / 64123	HGNCID:	20822	Length:	690	Species:	Homo sapiens

Alignment Length:	493	Identity:	113/493 - (22%)
Similarity:	176/493 - (35%)	Gaps:	153/493 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DFFDTVDISKAPRFSNG----SYLYEGLLIPAHLTAEYDYKLLA------DDSKEKVASHVRGCA 78
            |:.:.....||...|||    :::|...:.|  |.:..|..||.      .:.:|:|.|.|...:
Human   277 DYINIFPKRKAAYDSNGNVAVAFVYYKSIGP--LLSSSDNFLLKPQNYDNSEEEERVISSVISVS 339

  Fly    79 CHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRH--------FKEDLI 135
            ....|      |...:::|                  :..|||...|..|:        :..| .
Human   340 MSSNP------PTLYELEK------------------ITFTLSHRKVTDRYRSLCAFWNYSPD-T 379

  Fly   136 VQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKDDSI--RIAP 198
            :....:..||...|       .||.......:.|.|:..:..|.     ..:..||.:|  ||.
Human   380 MNGSWSSEGCELTY-------SNETHTSCRCNHLTHFAILMSSG-----PSIGIKDYNILTRIT- 431

  Fly   199 HFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLG--YFF 257
                          .:.|:|||||:.:.|..:.:..::::    :| |...|   ||||.  .|.
Human   432 --------------QLGIIISLICLAICIFTFWFFSEIQSTRTTIH-KNLCC---SLFLAELVFL 478

  Fly   258 LVLNVWKYSSGFC-VTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLY 321
            :.:|. ..:..|| :.||.|.|| .:|||.|:.:.||||.
Human   479 VGINT-NTNKLFCSIIAGLLHYF-FLAAFAWMCIEGIHLY------------------------- 516

  Fly   322 AWGIPLIMTAITYTADQVVKN----EKLRPRVGVG-------------KNCWIYTGDMTVMIYFY 369
                 ||:..:.|....:.||    ..|.|.|.||             |.||:.| :...:..|.
Human   517 -----LIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLST-ENNFIWSFI 575

  Fly   370 GPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEI 434
            ||..|:|..|::.|   .:.||.:.::..||..:....:.|......|  |.|..|:|.:|.|.:
Human   576 GPACLIILVNLLAF---GVIIYKVFRHTAGLKPEVSCFENIRSCARGA--LALLFLLGTTWIFGV 635

  Fly   435 LSFLLTKQQAWARALMVADYF----NWSQGTIIFVLFI 468
            |..:        .|.:|..|.    |..||..|| ||:
Human   636 LHVV--------HASVVTAYLFTVSNAFQGMFIF-LFL 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	38/196 (19%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	52/195 (27%)
ADGRL4	NP_071442.2	EGF_CA	58..>91	CDD:284955
		GAIN	139..330	CDD:293098	12/54 (22%)
		GPS	368..412	CDD:280071	8/51 (16%)
		7tm_4	424..660	CDD:304433	74/300 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810