DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl4 and adgrf6

DIOPT Version :9

Sequence 1:NP_788394.1 Gene:mthl4 / 36960 FlyBaseID:FBgn0034219 Length:517 Species:Drosophila melanogaster
Sequence 2:XP_021324327.1 Gene:adgrf6 / 565101 ZFINID:ZDB-GENE-041001-212 Length:11675 Species:Danio rerio


Alignment Length:443 Identity:91/443 - (20%)
Similarity:160/443 - (36%) Gaps:131/443 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 YFLNHELPGNEFTLFENGSLLRHWDKVELSKREY-------------CVQHLSFKDDSIRIAPHF 200
            |.||:|..|....:|.|.: |..||......:.|             |....||   |:.::|..
Zfish 11282 YGLNNETLGIPQCVFWNFN-LSVWDSYGCEAKPYISNGNETDIITCECNHTTSF---SMLMSPFS 11342

  Fly   201 CPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRN------------------LHGKCFI-- 245
            .........|:..|||.::.:.:.:.|...::....||                  :...|||  
Zfish 11343 IDNKVLDYITYIGVAISMASLILCIIIEAIVWRSTTRNDTSYMRHVSIVNIAISLLIADVCFIIG 11407

  Fly   246 -------------CYLASLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRI 297
                         |.....|:.:|:|||..|     ..::|..|.|.::|       |:....|:
Zfish 11408 AAISKEQPTPADRCSSVVFFMHFFYLVLFFW-----MLISALLLLYRTIM-------VLSHMSRV 11460

  Fly   298 KFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKN-CWIYTGD 361
            |..:.              |::: ::|.||:::.||..:       ...|:|.|.|. ||:...:
Zfish 11461 KMMII--------------AFSV-SYGAPLLISVITVAS-------TAGPQVYVSKQACWLNWNE 11503

  Fly   362 MTVMIYFYGPMLLLIAFNIIMF--VLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLR--- 421
            ...::.|..|.|.::|.|:::.  |||.:    :::.|....       |.:::....:.:|   
Zfish 11504 SKALLAFVIPALTIVAINLVVLIVVLSKL----LRRGVGDAT-------QPDEKHTLMVIVRCVA 11557

  Fly   422 -LFILMGLSWSFEILSFLLTKQQAWARALMVADYF---NWSQGTIIFVLFILKPSILKLIIAG-- 480
             |..:.||:|.|.|.:.:       :|.|.|...|   |..||..|.|..:|....::..:||  
Zfish 11558 FLTPIFGLTWGFGIGTMV-------SRELGVHVVFALLNSLQGFFILVFGVLLDGKVREALAGTL 11615

  Fly   481 GRQNLPGSHH-----------------NSRSKAARYNSTHTACEGSIADPNAY 516
            ..:||..|:.                 ..|.:...||.:..:.....|.||:|
Zfish 11616 SLRNLTSSNRTRSTSGGPSSSSGLGFFQRRRRRHMYNVSEASALSGPASPNSY 11668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl4NP_788394.1 Methuselah_N 23..201 CDD:284145 16/64 (25%)
7tm_4 213..>385 CDD:304433 40/207 (19%)
adgrf6XP_021324327.1 EGF_CA 216..249 CDD:214542
EGF_CA 568..602 CDD:214542
EGF_CA 920..954 CDD:214542
EGF_CA 1272..1306 CDD:214542
EGF_CA 1624..1658 CDD:214542
EGF_CA 1976..2013 CDD:214542
EGF_CA 2680..2717 CDD:214542
EGF_CA 3384..3417 CDD:214542
EGF_CA 3736..3769 CDD:214542
EGF_CA 4088..4121 CDD:214542
EGF_CA 4440..4477 CDD:214542
EGF_CA 4792..4829 CDD:214542
EGF_CA 5144..5181 CDD:214542
EGF_CA 5496..5533 CDD:214542
EGF_CA 5848..5885 CDD:214542
EGF_CA 6904..6941 CDD:214542
EGF_CA 7256..7293 CDD:214542
EGF_CA 7608..7641 CDD:214542
EGF_CA 7657..7695 CDD:311536
EGF_CA 7706..7739 CDD:214542
EGF_CA 7755..7789 CDD:214542
EGF_CA 7804..7842 CDD:311536
EGF_CA 7853..7886 CDD:214542
EGF_CA 7902..7940 CDD:311536
EGF_CA 7951..7984 CDD:214542
EGF_CA 8000..8038 CDD:311536
EGF_CA 8049..8082 CDD:214542
EGF_CA 8098..8131 CDD:214542
EGF_CA 8147..8185 CDD:311536
EGF_CA 8196..8229 CDD:214542
EGF_CA 8245..8278 CDD:214542
EGF_CA 8294..8332 CDD:311536
EGF_CA 8343..8376 CDD:214542
EGF_CA 8392..8430 CDD:311536
EGF_CA 8441..8474 CDD:214542
EGF_CA 8490..8523 CDD:214542
EGF_CA 8539..8577 CDD:311536
EGF_CA 8588..8622 CDD:214542
EGF_CA 8637..8675 CDD:311536
EGF_CA 8686..8719 CDD:214542
EGF_CA 8735..8769 CDD:214542
EGF_CA 8784..>8816 CDD:214542
EGF_CA 8879..8912 CDD:214542
EGF_CA 8928..>8960 CDD:214542
EGF_CA 9072..9110 CDD:311536
EGF_CA 9121..9154 CDD:214542
EGF_CA 9170..9208 CDD:311536
EGF_CA 9219..9253 CDD:214542
EGF_CA 9268..9306 CDD:311536
EGF_CA 9317..9350 CDD:214542
EGF_CA 9366..9404 CDD:311536
EGF_CA 9415..9449 CDD:214542
EGF_CA 9513..9550 CDD:311536
EGF_CA 9562..9595 CDD:214542
EGF_CA 9611..9649 CDD:311536
EGF_CA 9660..9694 CDD:214542
EGF_CA 9758..9796 CDD:311536
EGF_CA 9856..9894 CDD:311536
EGF_CA 9905..9939 CDD:214542
EGF_CA 9954..9992 CDD:311536
EGF_CA 10003..10037 CDD:214542
EGF_CA 10052..10090 CDD:311536
EGF_CA 10101..10134 CDD:214542
EGF_CA 10150..10188 CDD:311536
EGF_CA 10248..10286 CDD:311536
EGF_CA 10346..10384 CDD:311536
EGF_CA 10395..10428 CDD:214542
EGF_CA 10444..10482 CDD:311536
EGF_CA 10493..10527 CDD:214542
EGF_CA 10541..>10573 CDD:214542
Ig <10867..>10910 CDD:325142
GAIN 11087..>11205 CDD:318649
GPS 11292..11337 CDD:307782 10/48 (21%)
7tmB2_GPR116-like_Adhesion_VI 11345..11611 CDD:320598 63/317 (20%)
TM helix 1 11347..11372 CDD:320598 5/24 (21%)
TM helix 2 11387..11409 CDD:320598 3/21 (14%)
TM helix 3 11422..11449 CDD:320598 8/31 (26%)
TM helix 4 11463..11483 CDD:320598 6/34 (18%)
TM helix 5 11503..11532 CDD:320598 8/28 (29%)
TM helix 6 11549..11575 CDD:320598 7/25 (28%)
TM helix 7 11579..11604 CDD:320598 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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