DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and adgrl1a

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021330394.1	Gene:	adgrl1a / 562531	ZFINID:	ZDB-GENE-131127-267	Length:	1524	Species:	Danio rerio

Alignment Length:	401	Identity:	90/401 - (22%)
Similarity:	150/401 - (37%)	Gaps:	103/401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NHELPGNEFTLFENGSLLRHWDK-----VEL-SKREYC-VQHLSFKDDSIRIAPHFCPLSSEHSR 209
            ||..|...|..:...|:...|..     :|. |....| ..||:          :|..|...|..
Zfish   787 NHFSPNCSFWNYSERSMTGQWSSQGCRLIETNSTHTTCSCSHLT----------NFAVLMVHHEP 841

  Fly   210 --------------TWKTVAIVISLICIILTISVYLYVEKL---RNLHGK--CFICYLASLFLGY 255
                          ||  |.|||||:|:.:.||.:.::..|   ||...|  |...::|.|.
Zfish   842 DYPGRMHELILFVITW--VGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFIAELL--- 901

  Fly   256 FFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPE------NP 314
            |.:.::..:|.....:.||.|.:| .:|||.|:.:.||.           |:.:|.|      :.
Zfish   902 FLIGIDKTQYHIACPIFAGLLHFF-FLAAFSWMCLEGIQ-----------LYLMLVEVFESEYSR 954

  Fly   315 FRAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFN 379
            .:.|.|..:..|.::..|:...|.        ...|..|.||:.. |...:..|.||:..:|..|
Zfish   955 KKYYYLCGYCFPALVVGISAAIDY--------RSYGTKKACWLRV-DNYFIWSFIGPVSFIIMLN 1010

  Fly   380 IIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSF---------EIL 435
            ::..:::   ::.:.:|...|.........|....:.||  .|..|:||:|:|         .|:
Zfish  1011 LVFLMIT---LHKMIRNSSALKPDSSRLDNIKSWALGAI--ALLFLLGLTWAFGLLFINENTVIM 1070

  Fly   436 SFLLTKQQAWARALMVADYFNWSQGTIIFVLF-ILKPSI-------LKLIIAGGRQNLPGSHHNS 492
            ::|.|.             ||..||..||:.. .|:..:       |:......|.:...||.:.
Zfish  1071 AYLFTT-------------FNAFQGMFIFIFHCALQKKVHKEYSKCLRHSYCCSRTSTTSSHGSL 1122

  Fly   493 RSKAARYNSTH 503
            ::.|.|.|:.:
Zfish  1123 KNSALRTNNRY 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	11/55 (20%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	46/182 (25%)
adgrl1a	XP_021330394.1	Gal_Lectin	48..128	CDD:307994
		OLF	142..398	CDD:321983
		HormR	474..535	CDD:214468
		GAIN	545..765	CDD:318649
		GPS	789..836	CDD:197639	10/56 (18%)
		7tmB2_Latrophilin-1	849..1106	CDD:320673	70/300 (23%)
		TM helix 1	851..876	CDD:320673	11/26 (42%)
		TM helix 2	885..907	CDD:320673	6/24 (25%)
		TM helix 3	916..943	CDD:320673	11/38 (29%)
		TM helix 4	955..975	CDD:320673	4/19 (21%)
		TM helix 5	992..1021	CDD:320673	6/31 (19%)
		TM helix 6	1037..1064	CDD:320673	9/28 (32%)
		TM helix 7	1068..1093	CDD:320673	9/37 (24%)
		Latrophilin	1105..1524	CDD:308136	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810