DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and adgrv1

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_009300028.1	Gene:	adgrv1 / 415105	ZFINID:	ZDB-GENE-040624-6	Length:	6208	Species:	Danio rerio

Alignment Length:	392	Identity:	76/392 - (19%)
Similarity:	136/392 - (34%)	Gaps:	105/392 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 SLLRHWDKVE---LSKREYCVQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISL-------- 220
            ||...|::..   ||..::|    ...||:    .::...:..|...:...|.:.||
Zfish  5758 SLCLLWNQAAESWLSDGQFC----RLVDDT----QNYVECACSHLSIYTAYAEIESLASFNEAFY 5814

  Fly   221 ----ICI----------ILTISVYLYVEK-LRNLHGKCF---ICYLASLFLGYFFLVLNVWKYSS 267
                |||          ::.....::..| |.::...|.   ||:|.|.|.|..|        |.
Zfish  5815 AAGFICISGFALAMVSHLMCARFLMFAAKLLTHMMVACLGTQICFLVSAFRGRMF--------SE 5871

  Fly   268 GFCVTAGFLGYFSVMAAFFWLSVIGIHL-RIKFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTA 331
            ..|...|...::..::.|.|:.|..|:. :|   |..|..|   .|..:..|.|.:||:|.::..
Zfish  5872 DSCAALGLFFHYFHLSQFSWMLVQAINFWQI---LVMNDEH---TERRYLLYFLLSWGLPALVII 5930

  Fly   332 ITYTADQVVKNEKLRPRVGVGKNCW-------IYTGDMTVMIYFYG--------PMLLLIAFNII 381
            :...             |.:|...|       :..||:..:...|.        |::.|:...:|
Zfish  5931 VLVV-------------VLLGGFGWSIHSVYGLVQGDLCFIPNVYAALCTAALVPLICLVGVLVI 5982

  Fly   382 MFVLSAIYIYNIKKNVKGL--VHKQQTNQQINDQQ--MFAIFLRLFILMGLSWSFEILSFLLTKQ 442
            .     |:.|.:.:..|..  :::.:||.......  :||:...:.:..||..::..:
Zfish  5983 F-----IHAYQVTQQWKAYDDIYRGRTNSSEVPMMLYLFALVTLVCVWAGLHMAYRYI------- 6035

  Fly   443 QAWARALMVADYFNWSQGTIIF-VLFILKPSILKLIIAGGRQNLPGSHHNSRSKAARYNSTHTAC 506
              |...|:|  .||...|..:| |.|::.    ..:...|:.......:...|..:.|.||..|.
Zfish  6036 --WMLILLV--IFNIFLGLYVFSVYFVMH----NQLFWPGKATYTVEMNGHSSPDSIYQSTGAAT 6092

  Fly   507 EG 508
            .|
Zfish  6093 VG 6094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	8/36 (22%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	42/213 (20%)
adgrv1	XP_009300028.1	Calx-beta	138..230	CDD:295344
		Calx-beta	256..355	CDD:295344
		Calx-beta	766..853	CDD:295344
		Calx-beta	880..971	CDD:295344
		Calx-beta	996..1082	CDD:295344
		Laminin_G_3	1343..1484	CDD:290121
		Calx-beta	1576..1654	CDD:295344
		Calx-beta	1712..1794	CDD:295344
		Calx-beta	1849..1939	CDD:295344
		Calx-beta	1975..2065	CDD:295344
		Calx-beta	2105..2193	CDD:295344
		Calx-beta	2220..2310	CDD:295344
		Calx-beta	2590..2656	CDD:295344
		Calx-beta	2951..3039	CDD:295344
		Calx-beta	<3574..3614	CDD:295344
		Calx-beta	3641..3729	CDD:295344
		Calx-beta	<3788..3864	CDD:295344
		Calx-beta	4021..4112	CDD:295344
		Calx-beta	4257..4345	CDD:295344
		Calx-beta	4390..4480	CDD:295344
		Calx-beta	5003..5085	CDD:295344
		7tm_4	<5871..>5926	CDD:304433	15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900