DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl4 and Adgrf3

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006535799.1	Gene:	Adgrf3 / 381628	MGIID:	2685887	Length:	1059	Species:	Mus musculus

Alignment Length:	390	Identity:	90/390 - (23%)
Similarity:	142/390 - (36%)	Gaps:	97/390 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 GNEFTLFE--------NGSLLRH---WDKVELSKR-----EYCVQHLSFKDDSIRIAPH---FCP 202
            |..||..|        ||:|  |   ||......:     |.|..|.:....:..|..|   |..
Mouse   615 GQAFTQAEVIMDYEDMNGTL--HCVFWDHRVFQGQGGWSDEGCEVHAANASITQCICQHLTAFSI 677

  Fly   203 LSSEH-----------SRTWKTVAIVISLICIILTISVYLYVEKLRN-----LHGKCF---ICYL 248
            |.|:|           |:.....:::..|:|:.:...|:..|  :||     .|...|   ||.|
Mouse   678 LMSQHTVPENPTLDLLSQVGTGASVLALLVCLAIYGLVWRVV--VRNKVAFFRHTTLFNMVICLL 740

  Fly   249 A--SLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLP 311
            .  :.|||..||...   |.|..|:...||.:|..:|.|||:....:.|          .|:||
Mouse   741 VADTCFLGSPFLPSG---YHSLICLVTAFLCHFFYLATFFWMLAQALVL----------AHQLL- 791

  Fly   312 ENPFRAYNLYAWGIPLIMTAITYTADQVVKNEKL------RPRVGVGKNCWIYTGDMTVMIY-FY 369
               |..:.|....:..:|..:.|..........|      |..:..|| |::..|.  ||:| |.
Mouse   792 ---FVFHQLSKHVVLSLMVMLGYLCPLGFAGVTLGLYLPQRKYLWEGK-CFLNGGG--VMLYSFS 850

  Fly   370 GPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFIL---MGLSWS 431
            .|:|.::..|.::.|::.:.:.....:....|.|:|.        :..:...|.||   .||:|.
Mouse   851 EPVLAIVGVNGLVLVIAVLKLLRPSLSEGPTVEKRQA--------LVGVLKALLILTPIFGLTWG 907

  Fly   432 FEILSFLLTKQQAWARALMVADY----FNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHHNS 492
            ..:.:..        ...:|:.|    .|..||..|.|...|..   |.::...|:.|.||..::
Mouse   908 LGVATLF--------DGSIVSHYAFSILNSLQGVFILVFGCLTD---KKVLEALRKRLRGSRSSN 961

Fly 493 492
Mouse 962 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	15/62 (24%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	47/188 (25%)
Adgrf3	XP_006535799.1	HRM	352..398	CDD:367186
		GPS	635..678	CDD:366827	9/42 (21%)
		7tm_GPCRs	688..954	CDD:391938	68/306 (22%)
		TM helix 1	689..714	CDD:341315	3/24 (13%)
		TM helix 2	729..751	CDD:341315	8/21 (38%)
		TM helix 3	762..789	CDD:341315	8/36 (22%)
		TM helix 4	803..823	CDD:341315	2/19 (11%)
		TM helix 5	842..871	CDD:341315	9/30 (30%)
		TM helix 6	887..914	CDD:341315	6/34 (18%)
		TM helix 7	918..943	CDD:341315	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810