Protein Alignment mthl4 and mth

DIOPT Version :10

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 272/505 - (53%)
• Similarity: 363/505 - (71%)
• Gaps: 13/505 - (2%)

  Fly     1 MRILLIAVLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADD 65
            :||..:.::.|::.||.|:|..||:|||||||.|.:..|||||:||||:||.||.|||:::|.||
  Fly     7 LRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDD 71

  Fly    66 SKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHF 130
            ||:|||.|:|||.|.|:||:|||||....|....||.:||::||.:.|||:||||.||||.||||
  Fly    72 SKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHF 136

  Fly   131 KEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKD---D 192
            |.:||||.||..| |..|::|::....:::||||||:..||:|:|.|.|||||:|||:|.|   .
  Fly   137 KNELIVQWDLPMP-CDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNAT 200

  Fly   193 SIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFF 257
            |||||||.|.:..  |.|.:||.::.||||::|||:|||:|:||:||||||||||:..||:||.|
  Fly   201 SIRIAPHNCLIVP--SITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLF 263

  Fly   258 LVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYA 322
            |:|::|:.|..||..|||||||.|||||||||||.:||...|..:|:..:|.|.|:.|.|||.||
  Fly   264 LLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYA 328

  Fly   323 WGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSA 387
            ||:.:::|.||..||.:|:|:...||||...:|||||...:.|:||||||:.||||||.||:|:|
  Fly   329 WGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTA 393

  Fly   388 IYIYNIKKNVKGLVHKQQTNQQIN-DQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMV 451
            ..|..:||:::...|:|:..|::| |:|.:..||||||:||||||.||.|:.....|.||...:|
  Fly   394 KRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLV 458

  Fly   452 ADYFNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHH---NSRSKAAR 498
            |||.|||||.|||:||:||.|..:|:   ..:|.|.|..   ::||.|:|
  Fly   459 ADYLNWSQGIIIFILFVLKRSTWRLL---QERNHPKSTRSVISNRSMASR 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	108/180 (60%)
		7tmB3_Methuselah-like	205..477	CDD:410632	148/272 (54%)
		TM helix 1	207..232	CDD:410632	13/24 (54%)
		TM helix 2	241..263	CDD:410632	14/21 (67%)
		TM helix 3	271..298	CDD:410632	20/26 (77%)
		TM helix 4	315..335	CDD:410632	11/19 (58%)
		TM helix 5	361..390	CDD:410632	17/28 (61%)
		TM helix 6	411..438	CDD:410632	18/27 (67%)
		TM helix 7	446..471	CDD:410632	16/24 (67%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	108/180 (60%)
		7tmB3_Methuselah-like	219..488	CDD:410632	147/271 (54%)
		TM helix 2	247..269	CDD:410632	14/21 (67%)
		TM helix 3	277..304	CDD:410632	20/26 (77%)
		TM helix 4	321..341	CDD:410632	11/19 (58%)
		TM helix 5	367..396	CDD:410632	17/28 (61%)
		TM helix 6	418..445	CDD:410632	17/26 (65%)
		TM helix 7	453..478	CDD:410632	16/24 (67%)