DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl4 and mth

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_728521.1	Gene:	mth / 38058	FlyBaseID:	FBgn0023000	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	272/505 - (53%)
Similarity:	363/505 - (71%)	Gaps:	13/505 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRILLIAVLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADD 65
            :||..:.::.|::.||.|:|..||:|||||||.|.:..|||||:||||:||.||.|||:::|.||
  Fly     7 LRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDD 71

  Fly    66 SKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHF 130
            ||:|||.|:|||.|.|:||:|||||....|....||.:||::||.:.|||:||||.||||.||||
  Fly    72 SKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHF 136

  Fly   131 KEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKD---D 192
            |.:||||.||..| |..|::|::....:::||||||:..||:|:|.|.|||||:|||:|.|   .
  Fly   137 KNELIVQWDLPMP-CDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNAT 200

  Fly   193 SIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFF 257
            |||||||.|.:..  |.|.:||.::.||||::|||:|||:|:||:||||||||||:..||:||.|
  Fly   201 SIRIAPHNCLIVP--SITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLF 263

  Fly   258 LVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYA 322
            |:|::|:.|..||..|||||||.|||||||||||.:||...|..:|:..:|.|.|:.|.|||.||
  Fly   264 LLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYA 328

  Fly   323 WGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSA 387
            ||:.:::|.||..||.:|:|:...||||...:|||||...:.|:||||||:.||||||.||:|:|
  Fly   329 WGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTA 393

  Fly   388 IYIYNIKKNVKGLVHKQQTNQQIN-DQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMV 451
            ..|..:||:::...|:|:..|::| |:|.:..||||||:||||||.||.|:.....|.||...:|
  Fly   394 KRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLV 458

  Fly   452 ADYFNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHH---NSRSKAAR 498
            |||.|||||.|||:||:||.|..:|:   ..:|.|.|..   ::||.|:|
  Fly   459 ADYLNWSQGIIIFILFVLKRSTWRLL---QERNHPKSTRSVISNRSMASR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	108/180 (60%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	100/171 (58%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:284145	108/180 (60%)
mth	NP_728521.1	7tm_4	219..416	CDD:304433	108/196 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449687
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910