Protein Alignment mthl4 and mthl10

DIOPT Version :10

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 172/550 - (31%)
• Similarity: 287/550 - (52%)
• Gaps: 54/550 - (9%)

  Fly     4 LLIAVLFLLMPK-----------------SNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPA 51
            :|..|:|.|:|.                 .:..:| |:|:|||:::....|.||||.|.|.::||
  Fly    21 VLCLVVFRLIPGIPFGTYVMAERDHYHTIDDPNVP-CNFYDTVNLTGHRLFPNGSYDYYGTIVPA 84

  Fly    52 HLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIRFCCP--QYQKMQKSKCYGDMSEDELNKHDP 114
            .|...|||...:...:.:|..|||||.|..:.|:..|||  |....:...|..|.|::......|
  Fly    85 ELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCIIDHSDNRTWPDPP 149

  Fly   115 FVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPG-NEFTLFENGSLLRHWDKVELS 178
            .:|:|..:.|.:..:......:||  .:| ||:|:.|..|... :::.||||||:||..||:.:.
  Fly   150 MLNITFRNESTILVNMFTQFAIQS--FRP-CPKMFSLQPETNNWDDYLLFENGSMLRVDDKLLIR 211

  Fly   179 KREYCV--QHLSFKDDSIRIAPHFCPLSSEHSRTWKTV---AIVISLICIILTISVYLYVEKLRN 238
            |.|:|:  .:::..|....|.|..|.:..:|| |.|.:   |::.|:..::|||:|||.:.:|||
  Fly   212 KNEFCMVPTYVNESDMFYTIHPANCDMQDDHS-TVKIINSYAMMFSIPFMMLTIAVYLLIPELRN 275

  Fly   239 LHGKCFICYLASLFLGYFFLVLNVWKY---SSGF-CVTAGFLGYFSVMAAFFWLSVIGIHLRIKF 299
            .|||..:|||..|.:||..|.. |..|   ::|. |...|:..||..|.|:.|||||...|...|
  Fly   276 QHGKSLVCYLIGLSVGYSSLCY-VQLYQVDATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNF 339

  Fly   300 SLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVK-NEKLRPRVGVGKNCWIYTGDMT 363
            . .:..::|...:..|..|:||:|||.|:..|.||.|.|:.. ...|:|.:|.|..||:...:..
  Fly   340 R-GTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNWA 403

  Fly   364 VMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQ-----------MFA 417
            .|||||||:|.::..|.|||:::||.|:.:::.:..::..:.:.:.:..::           .|.
  Fly   404 AMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFG 468

  Fly   418 IFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFILKPSILKLIIAGGR 482
            :|||||::||::|..|::|:.:...:.|::...::|..|..||.:||:||::|..:..||    .
  Fly   469 LFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLI----T 529

  Fly   483 QNLPGSHHNSRSKAARYNSTHTACEGSIAD 512
            .........|..:.::|::..|:  .|:|:
  Fly   530 NRCSSVRDGSNQRQSQYSTKTTS--SSVAN 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	61/182 (34%)
		7tmB3_Methuselah-like	205..477	CDD:410632	97/290 (33%)
		TM helix 1	207..232	CDD:410632	11/27 (41%)
		TM helix 2	241..263	CDD:410632	9/21 (43%)
		TM helix 3	271..298	CDD:410632	11/26 (42%)
		TM helix 4	315..335	CDD:410632	10/19 (53%)
		TM helix 5	361..390	CDD:410632	14/28 (50%)
		TM helix 6	411..438	CDD:410632	11/37 (30%)
		TM helix 7	446..471	CDD:410632	8/24 (33%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	61/182 (34%)
		7tmB3_Methuselah-like	242..533	CDD:410632	99/297 (33%)
		TM helix 1	244..269	CDD:410632	9/24 (38%)
		TM helix 2	278..300	CDD:410632	10/22 (45%)
		TM helix 3	311..338	CDD:410632	11/26 (42%)
		TM helix 4	354..374	CDD:410632	10/19 (53%)
		TM helix 5	401..430	CDD:410632	14/28 (50%)
		TM helix 6	446..489	CDD:410632	11/42 (26%)
		TM helix 7	497..522	CDD:410632	8/24 (33%)