Protein Alignment mthl4 and mthl1

DIOPT Version :10

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 122/526 - (23%)
• Similarity: 211/526 - (40%)
• Gaps: 122/526 - (23%)

  Fly    21 PGCDFFDTVDI-----SKAPRFSNGS-YLYEGLLI--PAHLTAEYDYKLLA-DDSKEKVASHVRG 76
            |.|....|.:|     :....|.||: |:.|..|:  |:....:::..::. :||:...|.....
  Fly   113 PTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPD 177

  Fly    77 CACHLRPCIRFCCPQYQKMQKSKCYG------------DMSEDELNKHDPFVNVT--LSDGSVVR 127
            .|.:  |.::...|: ..::.|||.|            |:..:.....|..:.::  |.:||
  Fly   178 YAAN--PLVQQEPPK-ASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRLSPQLPEGS--- 236

  Fly   128 RHFKEDLIVQSDLAKPGCPRMYFLNHELPG--------NEFTLFENGSLLRHWDKVELSKREYCV 184
                    .|:....|.|.:        ||        .:..|..|.::|:...| .||..:||:
  Fly   237 --------YQTSYGLPDCGQ--------PGGYSIAGDWQDAKLDRNTAMLQLPHK-NLSAGQYCL 284

  Fly   185 QHLSFKDDSIRIAPHFCPLSSEH---------------------------SRTWKTVAIVISLIC 222
            :|.. ::..::|      ::.:|                           .:...|..|::|::.
  Fly   285 EHTQ-REGEVKI------IACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVF 342

  Fly   223 IILT-ISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYS----SGFCVTAGFLGYFSVM 282
            :..| ::.:|.......||.:|.|||:..|..|...|.:.....|    |..|.|......|..:
  Fly   343 LSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFL 407

  Fly   283 AAFFWLSVIGIHLRIKF------SLASN--CLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQV 339
            ||||||:.:..::...|      ||..|  .|.|.|       |:|||||.||::|.:....||:
  Fly   408 AAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYL-------YSLYAWGGPLLITFVAACVDQL 465

  Fly   340 VKNEKLRPRVGVGK-NCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHK 403
            .:...|||  |.|: .||....::::..|||||:.||:..||.:||.:...:      ..||..:
  Fly   466 PETTLLRP--GFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQL------TCGLWKR 522

  Fly   404 QQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLL-TKQQAWARALMVADYFNWSQGTIIFVLF 467
            ...........:..:.|:|.::||::|..:|||:|: .....|    ...|..|..||..||::.
  Fly   523 DDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGVW----FFTDLINALQGVFIFIVV 583

  Fly   468 ILKPSI 473
            ..:|.:
  Fly   584 GCQPQV 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	40/208 (19%)
		7tmB3_Methuselah-like	205..477	CDD:410632	81/311 (26%)
		TM helix 1	207..232	CDD:410632	5/52 (10%)
		TM helix 2	241..263	CDD:410632	7/21 (33%)
		TM helix 3	271..298	CDD:410632	8/26 (31%)
		TM helix 4	315..335	CDD:410632	9/19 (47%)
		TM helix 5	361..390	CDD:410632	11/28 (39%)
		TM helix 6	411..438	CDD:410632	8/26 (31%)
		TM helix 7	446..471	CDD:410632	6/24 (25%)
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	80/283 (28%)
		TM helix 1	327..352	CDD:410632	4/24 (17%)
		TM helix 2	362..384	CDD:410632	7/21 (33%)
		TM helix 3	396..423	CDD:410632	8/26 (31%)
		TM helix 4	441..461	CDD:410632	11/26 (42%)
		TM helix 5	485..515	CDD:410632	11/29 (38%)
		TM helix 6	530..557	CDD:410632	8/26 (31%)
		TM helix 7	562..587	CDD:410632	7/28 (25%)