DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl4 and Adgre1

DIOPT Version :9

Sequence 1:NP_788394.1 Gene:mthl4 / 36960 FlyBaseID:FBgn0034219 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_001007558.1 Gene:Adgre1 / 316137 RGDID:1359214 Length:932 Species:Rattus norvegicus


Alignment Length:402 Identity:91/402 - (22%)
Similarity:143/402 - (35%) Gaps:127/402 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 GSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHL 187
            |..|....|||.         ..|.:|.|.|..|..:                  |:|..||...
  Rat   563 GGTVTGERKEDF---------SKPIVYTLQHIQPKQK------------------SERSICVSWN 600

  Fly   188 SFKDDSIRIAPHFCPLSSEHSRTWKT-----------------------------VAIVISLICI 223
            :..:|. |..|..|. :.|.|.|...                             |..||||:|:
  Rat   601 TDVEDG-RWTPSGCE-TVEASETHTVCSCNRMTNLAIIMASGELTMEFSLYIISYVGTVISLVCL 663

  Fly   224 ILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWK--YSSGFCVTAGFLGYFSVM 282
            .|.|:.:|....::|    ||....:|    |||.....:..:.|  ..:...:.||||.|. .:
  Rat   664 ALAIATFLLFRAVQNHNTYLHLHLCVC----LFLAKILFLTGIDKTDNQTACAIIAGFLHYL-FL 723

  Fly   283 AAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNL-------YAWGIPLIMTAITYTADQVV 340
            |.|||:.|..:.|   |.:..|    |...|.|.:.|:       :.:|:|:::..|:.|     
  Rat   724 ACFFWMLVEAVML---FLMVRN----LKVVNYFSSRNIKMLHLCAFGYGLPVVVVIISAT----- 776

  Fly   341 KNEKLRP-RVGVGKNCWIYTGDMTVMIY-FYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHK 403
                :.| ..|:...||:.|  .|..|: |.||:.::|..|      ||:..:.:....:.|...
  Rat   777 ----VHPWGYGMHNRCWLNT--ETGFIWSFLGPVCMIITIN------SALLAWTLWVLRQKLCSV 829

  Fly   404 QQTNQQINDQQM--FAIFLRLFILMGLSWSF---------EILSFLLTKQQAWARALMVADYFNW 457
            .....::.|.::  |....::||| |.||..         .|:::|.|.             .|.
  Rat   830 NSEVSKLKDTRLLTFKAIAQIFIL-GCSWVLGIFQIGPLASIMAYLFTT-------------INS 880

  Fly   458 SQGTIIFVLFIL 469
            .||..||::..|
  Rat   881 LQGAFIFLIHCL 892

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl4NP_788394.1 Methuselah_N 23..201 CDD:284145 17/77 (22%)
7tm_4 213..>385 CDD:304433 50/215 (23%)
Adgre1NP_001007558.1 EGF_CA 33..63 CDD:238011
EGF_CA 81..>109 CDD:214542
EGF_CA 133..172 CDD:214542
EGF_CA 173..>203 CDD:214542
EGF_CA 222..255 CDD:214542
cEGF 245..275 CDD:289433
EGF_CA 272..>301 CDD:214542
EGF_CA 319..359 CDD:284955
Cell attachment site. /evidence=ECO:0000255 507..509
GPS 592..641 CDD:197639 10/50 (20%)
7tm_2 646..886 CDD:278432 67/282 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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