DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and mthl12

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	163/502 - (32%)
Similarity:	265/502 - (52%)	Gaps:	58/502 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVA- 71
            ::..:...|:|:||.|.:.:|::||...|. |.:|:||...|||:||.|:|||.|.|.||....
  Fly    12 IIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSKVPTEF 75

  Fly    72 SHVRGCACHLRPCIRFCCPQYQKMQKSKCYG-----------DMSEDELNKHDPFVNVTLSDGSV 125
            .::|||.|.:|||||.||.:...:...:|..           |::..::...||    ||::.::
  Fly    76 PNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDP----TLAELNM 136

  Fly   126 VRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFK 190
            :.::...:|::..:..:| |..:..|..:    |:|:.::||:|.|.....||..:||:....:.
  Fly   137 IPQYNSTELLILREQFQP-CDEIVSLKRD----EYTILKDGSILLHTSAEILSNDQYCLYPEIYS 196

  Fly   191 D--DSIRIAPHFCPLSSEHSRTWKTVA--IVISLICIILTISVYLYVEKLRNLHGKCFICYLASL 251
            |  ::|||....|     :......:|  .|||::..|||::|||.|||||||.|||.||.|.|:
  Fly   197 DFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSM 256

  Fly   252 FLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFR 316
            |:.||...::.::.....|..||::.||..|:::.|.||:..||...|:    .|:|..|:..|.
  Fly   257 FMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQYRFL 317

  Fly   317 AYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWI----YTG----DMTVMIYFYG--P 371
            .||.:.|....|.|.:.::.:|:.:|:.       ||:.|:    |.|    |.....:||.  |
  Fly   318 IYNTFVWCTAAIPTVVIFSMNQMWENDP-------GKSEWLPLVGYFGCSVKDWNSSSWFYSHIP 375

  Fly   372 MLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQ---QINDQQMFAIFLRLFILMGLSWSFE 433
            :::|.:||:|||||:||||:.:||.||......:.|.   :.| .|.:..|:|||::||.||..:
  Fly   376 IVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFN-VQTYIQFVRLFLIMGASWLLD 439

  Fly   434 ILSFLLTKQQAWARALM--VADYFNWSQGTIIFVLFILKPSILKLII 478
            .|:.|..........::  :..|.|.:.|.:||||.|||.|..|:|:
  Fly   440 QLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	57/191 (30%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	65/183 (36%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	57/191 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980