DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and Adgrg4

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001349814.1	Gene:	Adgrg4 / 236798	MGIID:	2685213	Length:	3025	Species:	Mus musculus

Alignment Length:	403	Identity:	93/403 - (23%)
Similarity:	156/403 - (38%)	Gaps:	110/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWD- 173
            |..||.:        ::.:|.:.|                 .|::.....|..|:..:.|..|:
Mouse  2564 NLADPVI--------IILKHIQGD-----------------WNYDQVYCAFWDFDTNNGLGGWNP 2603

  Fly   174 ---KVELSKREYCV---QHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTIS---- 228
               |::.|...|.:   .||:          ||..| .:.||:  ||..|...|.:|:|.:
Mouse  2604 SGCKLKESNINYTICQCNHLT----------HFGVL-MDLSRS--TVDAVNERILVIITYTGCGI 2655

  Fly   229 ----------VYLYVEKLRNLHGKCFICYL--ASLFLGYFFLVLNVWKYS---SGFCVTAGFLGY 278
                      .|:...|||..:....:..|  |.|.|...||| |.|..|   .|.|:||....:
Mouse  2656 SSIFLGIAMVTYIAFHKLRKDYPSKILINLCTALLMLNLAFLV-NSWLTSFQKVGLCITAAVALH 2719

  Fly   279 FSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKNE 343
            :.::.:..|:.:..:|:  .|:|. ...:..:| |....:.|..||||.|..||..:    |:.:
Mouse  2720 YFLLVSLTWMGLEAVHM--YFALV-KVFNTYIP-NYILKFCLAGWGIPAITVAIILS----VRKD 2776

  Fly   344 ---KLRPRVGVGKNCWI---YTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVH 402
               .|.|....   |||   :...::|:.||    .|:...|:.||....:.:.::|.      .
Mouse  2777 LYGTLSPTTPF---CWIKDDHIFYISVVAYF----CLIFLMNLSMFCTVLVQLTSVKS------Q 2828

  Fly   403 KQQTNQQ--INDQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADYF----NWSQGT 461
            .|:|.::  :||.:.   .:.|..|:||:|.|...        ||....:...|.    |..||.
Mouse  2829 SQKTRKKMILNDLKG---TISLTFLLGLTWGFAFF--------AWGPVRIFFLYLFAICNTLQGF 2882

  Fly   462 IIFVLF-ILKPSI 473
            :|||.: ::|.|:
Mouse  2883 LIFVFYCVMKESV 2895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	16/97 (16%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	51/196 (26%)
Adgrg4	NP_001349814.1	LamG	<54..162	CDD:328935
		DnaJ	<276..746	CDD:333066
		GPS	2587..2629	CDD:307782	11/51 (22%)
		7tmB2_GPR112	2642..2903	CDD:320663	70/287 (24%)
		TM helix 1	2644..2669	CDD:320663	4/24 (17%)
		TM helix 2	2679..2701	CDD:320663	8/22 (36%)
		TM helix 3	2712..2739	CDD:320663	4/28 (14%)
		TM helix 4	2754..2770	CDD:320663	7/15 (47%)
		TM helix 5	2793..2816	CDD:320663	6/26 (23%)
		TM helix 6	2838..2863	CDD:320663	9/35 (26%)
		TM helix 7	2867..2892	CDD:320663	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910