DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and ADGRL1

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_016881964.1	Gene:	ADGRL1 / 22859	HGNCID:	20973	Length:	1506	Species:	Homo sapiens

Alignment Length:	392	Identity:	94/392 - (23%)
Similarity:	157/392 - (40%)	Gaps:	86/392 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NHELPGNEFTLFENGSLLRHWDK-----VELSK-REYCV-QHLSFKDDSIRIAPHFCPLSSEHS- 208
            ||......|..:...|:|.:|..     ||.:| ...|. .||:          :|..|.:...
Human   804 NHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLT----------NFAVLMAHREI 858

  Fly   209 ------------RTWKTVAIVISLICIILTISVYLYVEKL---RNLHGK--CFICYLASLFLGYF 256
                        .||  |.|||||:|:.:.||.:.::..|   ||...|  |...:||.|.   |
Human   859 YQGRINELLLSVITW--VGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELL---F 918

  Fly   257 FLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPE------NPF 315
            .:.::..:|.....:.||.|.|| .:|||.||.:.|:|           |:.||.|      :..
Human   919 LVGIDKTQYEIACPIFAGLLHYF-FLAAFSWLCLEGVH-----------LYLLLVEVFESEYSRT 971

  Fly   316 RAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNI 380
            :.|.|..:..|.::..|....|.        ...|..|.||:.. |...:..|.||:..:|..|:
Human   972 KYYYLGGYCFPALVVGIAAAIDY--------RSYGTEKACWLRV-DNYFIWSFIGPVSFVIVVNL 1027

  Fly   381 IMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAI-FLRLFILMGLSWSFEILSFLLTKQQA 444
            :..:::      :.|.::.....:..:.::::.:.:|: .:.|..|:||:|:|.:|  .:.|:..
Human  1028 VFLMVT------LHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLL--FINKESV 1084

  Fly   445 WARALMVADYFNWSQGTIIFVLF-ILKPSILKLIIAGGRQNL------PGSHHNS-RSKAARYNS 501
            ....|...  ||..||..|||.. .|:..:.|......|.:.      ||..|.| ::.|.|.|:
Human  1085 VMAYLFTT--FNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNT 1147

  Fly   502 TH 503
            .:
Human  1148 RY 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	12/55 (22%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	50/182 (27%)
ADGRL1	XP_016881964.1	Gal_Lectin	48..128	CDD:396628
		OLF	143..399	CDD:413369
		PHA03247	<399..503	CDD:223021
		HormR	484..547	CDD:214468
		GAIN	557..782	CDD:406802
		GPS	806..858	CDD:197639	12/61 (20%)
		7tmB2_Latrophilin-1	865..1122	CDD:320673	72/292 (25%)
		TM helix 1	868..892	CDD:320673	11/25 (44%)
		TM helix 2	901..922	CDD:320673	7/23 (30%)
		TM helix 3	932..954	CDD:320673	10/22 (45%)
		TM helix 4	973..989	CDD:320673	3/15 (20%)
		TM helix 5	1008..1031	CDD:320673	6/22 (27%)
		TM helix 6	1058..1080	CDD:320673	8/23 (35%)
		TM helix 7	1084..1109	CDD:320673	8/26 (31%)
		Latrophilin	1121..1506	CDD:396778	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810