Protein Alignment mthl4 and ADGRG3

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_005255899.1
• Gene: ADGRG3 / 222487
• HGNCID: 13728
• Length: 596
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 114/576 - (19%)
• Similarity: 190/576 - (32%)
• Gaps: 180/576 - (31%)

  Fly     2 RILLIAVLFLLMPKSNAEI----------PGCDFFDTVDISKAPR--FSNGSYLYEGLLIPAHLT 54
            |:.|...||..:|.:.:.:          ||..|       |.||  ..:||.:....|:...:.
Human   130 RVRLPKSLFRSLPGNRSVVRLAVTILDIGPGTLF-------KGPRLGLGDGSGVLNNRLVGLSVG 187

  Fly    55 AEYDYKLLADDSKEKVASHVR-------------------------GCACHLRPCIRFCCPQYQK 94
            ..:..||.  :..|.|.||.|                         ||:..:||....||
Human   188 QMHVTKLA--EPLEIVFSHQRPPPNMTLTCVFWDVTKGTTGDWSSEGCSTEVRPEGTVCC----- 245

  Fly    95 MQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGC-PRMYFLNHELPGN 158
                 |      |.|......:..||...:|   |      :.:.:::.|| ..|.||
Human   246 -----C------DHLTFFALLLRPTLDQSTV---H------ILTRISQAGCGVSMIFL------- 283

  Fly   159 EFTLFENGSL---LRHWDKVELSKREY--------CVQHLSFKDDSIRIAPH----FCPLSSEHS 208
            .||:.....|   |.|....:.::.:.        |.:.|. :.:.:..||.    ...||.|..
Human   284 AFTIILYAFLSPGLGHGPHPQQAECDLPAGRIAGPCERGLE-RQEKLPPAPQGGAWHLRLSRERF 347

  Fly   209 RTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYSSG---FC 270
            ::.....|.::                   |.|..|:..||       ||| ||...|.|   .|
Human   348 KSEDAPKIHVA-------------------LGGSLFLLNLA-------FLV-NVGSGSKGSDAAC 385

  Fly   271 VTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAY--------NLYAWGIPL 327
            ...|.:.::.::.||.|:.:...||            .||....|..|        :|..||:|.
Human   386 WARGAVFHYFLLCAFTWMGLEAFHL------------YLLAVRVFNTYFGHYFLKLSLVGWGLPA 438

  Fly   328 IMTAITYTADQ----VVKNEKLRPRVGVGKNCWIYTGDMTVMIYF--YGPMLLLIAFNIIMFVLS 386
            :|...|.:|:.    .:::.:.|..:.:   ||...|.....:|.  :|..|:...|.:::..|.
Human   439 LMVIGTGSANSYGLYTIRDRENRTSLEL---CWFREGTTMYALYITVHGYFLITFLFGMVVLALV 500

  Fly   387 AIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMV 451
            ...|:.:.:       .....::..:::.....|.|..|:|::|...|.:.|      ....:.:
Human   501 VWKIFTLSR-------ATAVKERGKNRKKVLTLLGLSSLVGVTWGLAIFTPL------GLSTVYI 552

  Fly   452 ADYFNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHHNSRSKAARYNSTHTACE 507
            ...||..||..|...|    :||         .||.......|..||.:..|:|.:
Human   553 FALFNSLQGVFICCWF----TIL---------YLPSQSTTVSSSTARLDQAHSASQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	41/220 (19%)
		7tm_4	213..>385	CDD:304433	39/188 (21%)
ADGRG3	XP_005255899.1	GPS	213..255	CDD:280071	9/57 (16%)
		7tm_4	355..564	CDD:304433	52/263 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810