Protein Alignment mthl4 and ADGRG5

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001291305.1
• Gene: ADGRG5 / 221188
• HGNCID: 19010
• Length: 528
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 90/535 - (16%)
• Similarity: 173/535 - (32%)
• Gaps: 173/535 - (32%)

  Fly    17 NAEIPG------------------CDF----FDTVDISKAPRFSNGSYL--YEGLLIPAHLTAEY 57
            |...||                  |||    ..:..:.:.|: :.|.:.  ...:..||.||.:
Human    58 NTSFPGYNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQ-AGGQHARGQHAMQFPAELTRD- 120

  Fly    58 DYKLLADDSKEKVASHVRGCACHLRP------CIRFCCPQYQKMQKSKCYGDMSEDELNK---HD 113
                                ||..||      ||.|....:.|            ||.|.   ::
Human   121 --------------------ACKTRPRELRLICIYFSNTHFFK------------DENNSSLLNN 153

  Fly   114 PFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFT--LFENGSLLRHWD--- 173
            ..:...||.|.|  .:.::.:.:.           ::.|..|.|...|  .::.|:..:.|.
Human   154 YVLGAQLSHGHV--NNLRDPVNIS-----------FWHNQSLEGYTLTCVFWKEGARKQPWGGWS 205

  Fly   174 ----KVELSKREYCV---QHLSFKDDSIRIAPHFCPLSSEHSRTW-KTVAIVISLICIILTISVY 230
                :.|.......:   .||::....::::|...|.......|: ..|...||::..::|:.::
Human   206 PEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLH 270

  Fly   231 LYVEKL--------RNLHGKCFICYLASLFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVMAA 284
            .:..|.        .|||.       :.|.|...||:...:..|   ...|.......::::::.
Human   271 FHFRKQSDSLTRIHMNLHA-------SVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSC 328

  Fly   285 FFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLY-----------AWGIPLIMTAITYTADQ 338
            ..|:::.|.:|.:...               |.||:|           .||.|.::..::.:...
Human   329 LTWMAIEGFNLYLLLG---------------RVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKS 378

  Fly   339 VVKNEKLRPRVGVGKN---------CWIYTGDM-TVMIYFYGPMLLLIAFNIIMFVLSAIYIYNI 393
            .|......|.....:|         ||:.:..: :|::..||.:..|  ||:::...:...:..:
Human   379 SVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSL--FNLVVLAWALWTLRRL 441

  Fly   394 KKNVKG----LVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEILSF--LLTKQQAWARALMVA 452
            ::....    ..|...|            .|.|.:|:|.:|:....||  .|..|      |.:.
Human   442 RERADAPSVRACHDTVT------------VLGLTVLLGTTWALAFFSFGVFLLPQ------LFLF 488

  Fly   453 DYFNWSQGTIIFVLF 467
            ...|...|..:|:.|
Human   489 TILNSLYGFFLFLWF 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	34/204 (17%)
		7tm_4	213..>385	CDD:304433	35/203 (17%)
ADGRG5	NP_001291305.1	GPS	187..232	CDD:307782	6/44 (14%)
		7tmB2_GPR114	245..518	CDD:320559	52/301 (17%)
		TM helix 1	247..272	CDD:320559	5/24 (21%)
		TM helix 2	281..303	CDD:320559	7/28 (25%)
		TM helix 3	315..342	CDD:320559	3/26 (12%)
		TM helix 4	355..375	CDD:320559	3/19 (16%)
		TM helix 5	409..438	CDD:320559	6/30 (20%)
		TM helix 6	451..478	CDD:320559	8/38 (21%)
		TM helix 7	482..507	CDD:320559	6/28 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810