DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	333	Identity:	80/333 - (24%)
Similarity:	139/333 - (41%)	Gaps:	71/333 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 CVQHLSF-KDDSIRIAPHF--------CPLSSEH--SRTWKTVAIV------ISLICIILTISVY 230
            ||.|... ..::|.:..||        .|.|:..  .|..|.:..:      ||.|....|:..|
Mouse   830 CVAHSDLDAGETICLCSHFTHFGVLMDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTY 894

  Fly   231 LYVEKLRNLHGKCFICYLAS--LFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVMAAFFWLSV 290
            :..||||..:....:..|:|  |||...|| |:.|..|   :|.|.....|.:|.::|.|.|:.:
Mouse   895 VAFEKLRRDYPSKILMNLSSALLFLNLIFL-LDGWVTSFGVAGLCTAVAALLHFFLLATFTWMGL 958

  Fly   291 IGIHLRIKFSLASNC-LHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKN 354
            ..||:.|......|. :||.:.:     :.:..||:|.::.:|...:.:  :|| :..:...||:
Mouse   959 EAIHMYIALVKVFNTYIHRYILK-----FCIIGWGLPALVVSIILVSRR--QNE-VYGKESYGKD 1015

  Fly   355 -----CWIYTGDMTVMIY-----FYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQ 409
                 |||..   .|:.|     ::|.|..|   |:.||::..:.|..  :|.|      ::|:.
Mouse  1016 QDDEFCWIQD---PVVFYVSCAGYFGVMFFL---NVAMFIVVMVQICG--RNGK------RSNRT 1066

  Fly   410 INDQQM--FAIFLRLFILMGLSWSFEILSFLLTKQQAWARA----LMVADYFNWSQGTIIFVLF- 467
            :.::.:  ....:.|..|:|::|.|...        ||...    :.:...||..||..||:..
Mouse  1067 LREEVLRNLRSVVSLTFLLGMTWGFAFF--------AWGPLNIPFMYLFSIFNSLQGLFIFIFHC 1123

  Fly   468 ILKPSILK 475
            .:|.::.|
Mouse  1124 AMKENVQK 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	6/26 (23%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	51/193 (26%)
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001
		LamG	188..347	CDD:389952
		HRM	543..588	CDD:382965
		GPS	809..854	CDD:366827	6/23 (26%)
		7tm_GPCRs	869..1137	CDD:391938	71/294 (24%)
		TM helix 1	871..896	CDD:341315	5/24 (21%)
		TM helix 2	906..928	CDD:341315	8/22 (36%)
		TM helix 3	939..966	CDD:341315	7/26 (27%)
		TM helix 4	981..997	CDD:341315	3/20 (15%)
		TM helix 5	1026..1049	CDD:341315	7/25 (28%)
		TM helix 6	1072..1097	CDD:341315	6/32 (19%)
		TM helix 7	1101..1126	CDD:341315	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810