DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and ADGRE1

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_011526096.1	Gene:	ADGRE1 / 2015	HGNCID:	3336	Length:	978	Species:	Homo sapiens

Alignment Length:	484	Identity:	106/484 - (21%)
Similarity:	172/484 - (35%)	Gaps:	184/484 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 YGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRM----------------- 148
            |.|:....:||.....||||            ||:.:.|..|.||..:
Human   524 YLDIESKVINKECSEENVTL------------DLVAKGDKMKIGCSTIEESESTETTGVAFVSFV 576

  Fly   149 ---------YFLNHELP--GNEFTLFEN----GSLLRHWDKVELS----------------KREY 182
                     :|.:|:.|  .:|..|..|    |.::....|...|                :|..
Human   577 GMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPI 641

  Fly   183 CV---------QHLSF--------------------------------KDDSIRIAPHFCPLSSE 206
            ||         :..||                                .|.|:.|..|
Human   642 CVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISH------- 699

  Fly   207 HSRTWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYL--ASLFLGYFFLVLNVWKY 265
                   |.|:|||:|::|.|:.:|....:||    ||....:|.|  .:|||.......|
Human   700 -------VGIIISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDN---- 753

  Fly   266 SSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNL-------YAW 323
            ..|..:.||||.|. .:|.|||:.|..:   |.|.:..|    |...|.|.:.|:       :.:
Human   754 KMGCAIIAGFLHYL-FLACFFWMLVEAV---ILFLMVRN----LKVVNYFSSRNIKMLHICAFGY 810

  Fly   324 GIPLIMTAITYTADQVVKNEKLRPR-VGVGKNCWIYTGDMTVMIY-FYGPMLLLIAFNIIMFVLS 386
            |:|:::         ||.:..::|: .|:...||:.|  .|..|: |.||:..:|..|.::...:
Human   811 GLPMLV---------VVISASVQPQGYGMHNRCWLNT--ETGFIWSFLGPVCTVIVINSLLLTWT 864

  Fly   387 AIYIYNIKKNVKGLVHKQQTNQQINDQQM--FAIFLRLFILMGLSW---SFEI------LSFLLT 440
               ::.:::.:..:..:..|   :.|.::  |..|.:|||| |.||   .|:|      :::|.|
Human   865 ---LWILRQRLSSVNAEVST---LKDTRLLTFKAFAQLFIL-GCSWVLGIFQIGPVAGVMAYLFT 922

  Fly   441 KQQAWARALMVADYFNWSQGTIIFVLFIL 469
                         ..|..||..||::..|
Human   923 -------------IINSLQGAFIFLIHCL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	32/188 (17%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	53/186 (28%)
ADGRE1	XP_011526096.1	EGF_CA	33..62	CDD:238011
		EGF_CA	80..114	CDD:214542
		EGF_CA	132..171	CDD:214542
		EGF_CA	172..206	CDD:214542
		EGF_CA	224..260	CDD:214542
		EGF_CA	264..297	CDD:214542
		EGF_CA	313..>342	CDD:214542
		EGF_CA	360..400	CDD:284955
		GPS	638..687	CDD:197639	5/48 (10%)
		7tm_2	691..932	CDD:278432	75/297 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810