DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl4 and lat-1

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	453	Identity:	95/453 - (20%)
Similarity:	163/453 - (35%)	Gaps:	125/453 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRH- 171
            ::...|..|.:..:|.:.||:......||.:.|.:.|..|.  :.:.......|.:...|.:||
Worm   430 QMTPSDVTVAIAGTDQTEVRKRRVVSRIVGASLIENGKERR--VENLTQPVRITFYHKESSVRHL 492

  Fly   172 -------WDKVELS-KREYCVQHLSFKDDSIRIA-----PHFCPLS-------SEHSRTWKT--- 213
                   |:..||. |...|  .||:.:.::...     .||..|.       :|..:|..|
Worm   493 SNPTCVWWNHHELKWKPSGC--KLSYHNKTMTSCDCTHLTHFAVLMDVRGHDLNEIDQTLLTLLT 555

  Fly   214 -VAIVISLICIILTISVYLYVEKLRNLHGKCFI----CYLASLFLGYFFLVLNVWKYSSGF-CVT 272
             |..:||:||::||...||...  ||...:.||    |  .||.:.....:..:.:..... |..
Worm   556 YVGCIISIICLLLTFFAYLIFS--RNGGDRVFIHENLC--LSLAIAEITFLAGITRTEDSLQCGI 616

  Fly   273 AGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLL----PENPFR-AYNLYAWGIPLIMTAI 332
            ......:..::|..|:.:.|.|           :||:|    |.:|.| .|.|..:..|.|:|.:
Worm   617 IAVALMYMFLSALTWMLLEGYH-----------IHRMLTEVFPSDPRRFTYLLVGYIPPAIITLV 670

  Fly   333 TYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIY------ 391
            .|..:.        ...|...:||:.|.:..:. :|.||...:...|.::.|.:...:|
Worm   671 AYLYNS--------DGFGTPDHCWLSTQNNFIW-FFAGPACFIFCANSLVLVKTLCTVYQHTSGG 726

  Fly   392 ------------NIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLLTKQQA 444
                        :|:..|||                   .|.|..|:|::|.|.:.
Worm   727 YLPCRHDVDSGRSIRNWVKG-------------------SLALASLLGVTWIFGLF--------- 763

  Fly   445 W---ARALMVADYF---NWSQGTIIFVLFILKPSILKLII--------AGGRQNLPGSH--HN 491
            |   :|::::|..|   |..||..||:..::....::..:        .||..|...:|  ||
Worm   764 WVEDSRSIVMAYVFTISNSLQGLFIFLFHVVFAEKMRKDVGHWMYRRGCGGSSNSSPNHKRHN 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	22/106 (21%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	42/185 (23%)
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468
		GAIN	258..462	CDD:406802	7/31 (23%)
		GPS	493..541	CDD:197639	10/49 (20%)
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	64/311 (21%)
		TM helix 1	551..575	CDD:320556	9/23 (39%)
		TM helix 2	584..605	CDD:320556	5/22 (23%)
		TM helix 3	615..637	CDD:320556	2/21 (10%)
		TM helix 4	655..671	CDD:320556	5/15 (33%)
		TM helix 5	690..713	CDD:320556	4/23 (17%)
		TM helix 6	744..766	CDD:320556	10/49 (20%)
		TM helix 7	771..796	CDD:320556	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910