DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and mth-2

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001364698.1	Gene:	mth-2 / 173752	WormBaseID:	WBGene00017947	Length:	971	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	69/340 - (20%)
Similarity:	118/340 - (34%)	Gaps:	107/340 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 TVAIVISLICII----LT-ISVYLYVEKL-----------RNLHGKCFIC--YLASLFLGY-FFL 258
            |:..|::.:.|:    || .|:..|:..|           .||..:.|:.  |...|.|.| ||.
Worm   667 TLGYVVNGLSIVSLAFLTFFSISAYINSLANSRLYSYVRGHNLARRDFLALIYHFDLLLFYVFFT 731

  Fly   259 VLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYAW 323
            |.:....|...|.....:.|..::.:.| |::        |....|.| ..||...:|..|:...
Worm   732 VFSNQDVSGDMCTAMAAVMYALLLCSLF-LTI--------FQALRNIL-VFLPTPAYRLLNICFG 786

  Fly   324 GIPLIMTAI-----------TYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIA 377
            .:|:::|::           .:|        |...|...  .||:....:...|..  |:.:|:.
Worm   787 TVPVLITSVALPFILSIFLLVFT--------KFFDRQDC--FCWVRPDYIVAAIII--PVTVLLL 839

  Fly   378 FNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFIL---MGLSWSFEILSFLL 439
            ..:   |.::..||.:   ..|:..|........|..:....:.:.::   :||.|   ||.|
Worm   840 STV---VCTSFMIYKV---FCGMKRKFSQGGHHYDPNVITKIVSIVVMQISLGLPW---ILQF-- 893

  Fly   440 TKQQAWARALMVADYFN-W---------SQGTIIFVLFILK-------PSILKLIIAGGRQNLPG 487
                    ..:.:.|.. |         |||||:.::|:.|       .|.||
Worm   894 --------GTLYSPYTTFWHYTFTIVLGSQGTILLLIFLYKRYRAWQADSTLK------------ 938

  Fly   488 SHHNSRSKAARYNST 502
                ||.::...|||
Worm   939 ----SRGQSYSKNST 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	40/201 (20%)
mth-2	NP_001364698.1	GPS	607..656	CDD:197639
		7tm_GPCRs	662..933	CDD:421689	61/306 (20%)
		TM helix 1	664..690	CDD:410628	6/22 (27%)
		TM helix 2	706..735	CDD:410628	10/28 (36%)
		TM helix 4	779..803	CDD:410628	4/23 (17%)
		TM helix 5	824..852	CDD:410628	6/32 (19%)
		TM helix 6	868..897	CDD:410628	7/41 (17%)
		TM helix 7	902..927	CDD:410628	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8337
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950