DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and Adgrl2

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_599235.3	Gene:	Adgrl2 / 171447	RGDID:	620835	Length:	1487	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	82/339 - (24%)
Similarity:	133/339 - (39%)	Gaps:	82/339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 TWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWK--YSSG 268
            ||  |.||:||:|:.:.|..:.:...|::    :|....|    :||:..|..::.:.|  |:..
  Rat   855 TW--VGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCI----NLFIAEFIFLIGIDKTQYTIA 913

  Fly   269 FCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAIT 333
            ..|.||.|.:| .:|||.|:.:.|:.|.:       .|..:......|....|..|.....|.:.
  Rat   914 CPVFAGLLHFF-FLAAFSWMCLEGVQLYL-------MLVEVFESEYSRKKYYYVAGYLFPATVVG 970

  Fly   334 YTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVK 398
            .:|....|:      .|..:.||::. |...:..|.||:..:|..|||..|::   :..:.|:..
  Rat   971 VSAAIDYKS------YGTLEACWLHV-DNYFIWSFIGPVTFIILLNIIFLVIT---LCKMVKHSN 1025

  Fly   399 GLVHKQQTNQQINDQQM--------------------------FAIFLRLFILMGLSWSFEILSF 437
            .|.......:.||:.::                          ||    |..|:||:|||.:|
  Rat  1026 TLKPDSSRLENINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFA----LLCLLGLTWSFGLL-- 1084

  Fly   438 LLTKQQAWARALMVADYFNWSQGTIIFVLF-ILKPSILK--------LIIAGGRQNLPGSHHNSR 493
            .:.::......|..|  ||..||..||:.. .|:..:.|        ....||   ||....:|.
  Rat  1085 FVNEETVVMAYLFTA--FNAFQGLFIFIFHCALQKKVRKEYAKCFRHWYCCGG---LPTESPHSS 1144

  Fly   494 SKA------ARYNS 501
            .||      |||:|
  Rat  1145 VKASTSRTSARYSS 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	44/177 (25%)
Adgrl2	NP_599235.3	Gal_Lectin	49..129	CDD:396628
		OLF	142..398	CDD:413369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..462
		HormR	469..533	CDD:214468
		GAIN	542..764	CDD:406802
		GPS	788..840	CDD:197639
		7tm_GPCRs	848..1129	CDD:421689	71/305 (23%)
		TM helix 1	850..875	CDD:410628	9/21 (43%)
		TM helix 2	884..906	CDD:410628	5/25 (20%)
		TM helix 3	915..942	CDD:410628	11/34 (32%)
		TM helix 4	954..974	CDD:410628	3/19 (16%)
		TM helix 5	991..1020	CDD:410628	9/31 (29%)
		TM helix 6	1036..1087	CDD:410628	12/56 (21%)
		TM helix 7	1091..1116	CDD:410628	8/26 (31%)
		Latrophilin	1128..1487	CDD:396778	11/34 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1160		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1386..1428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810