DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl4 and Adgrl4

DIOPT Version :9

Sequence 1:NP_788394.1 Gene:mthl4 / 36960 FlyBaseID:FBgn0034219 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_573485.2 Gene:Adgrl4 / 170757 MGIID:2655562 Length:739 Species:Mus musculus


Alignment Length:442 Identity:106/442 - (23%)
Similarity:158/442 - (35%) Gaps:140/442 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 DSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRH 129
            :.||||.|.|...:....|      |...:::|                  :..|||       |
Mouse   374 EGKEKVISSVISASISSNP------PTLYELEK------------------ITFTLS-------H 407

  Fly   130 FKEDLIVQSDLAKPGCPRMYFLNHELPG-NEFTLFENGSLLRHWDKVELSKREYCVQHLSFKDDS 193
            .|     .||..:..|.   |.|:.:.. |..:....|..|.|.:....|.|  | .||:     
Mouse   408 VK-----LSDKHRTQCA---FWNYSVDAMNNGSWSTEGCELTHSNDTHTSCR--C-SHLT----- 456

  Fly   194 IRIAPHFCPLSSEHSRTW----------KTVAIVISLICIILTISVYLYVEKLRN----LHGKCF 244
                 ||..|.|..|...          ..:.|:|||||:.:.|..:.:..::::    :| |..
Mouse   457 -----HFAILMSSTSSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIH-KNL 515

  Fly   245 ICYLASLFLG--YFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLH 307
            .|   ||||.  .|.:.:|:........:.||.|.|| .:|||.|:.:.||||.           
Mouse   516 CC---SLFLAELVFLIGININTNKLVCSIIAGLLHYF-FLAAFAWMCIEGIHLY----------- 565

  Fly   308 RLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKN----EKLRPRVGVG-------------KNC 355
                               ||:..:.|....:.||    ..|.|.|.||             |.|
Mouse   566 -------------------LIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVC 611

  Fly   356 WIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFL 420
            |:.| :...:..|.||..|:|..|::.|   .:.||.:.::..||  |.:.:...|.:......|
Mouse   612 WLST-ENNFIWSFIGPACLIILVNLLAF---GVIIYKVFRHTAGL--KPEVSCYENIRSCARGAL 670

  Fly   421 RLFILMGLSWSFEILSFLLTKQQAWARALMVADYF----NWSQGTIIFVLFI 468
            .|..|:|.:|.|.:|..:        .|.:|..|.    |..||..|| ||:
Mouse   671 ALLFLLGTTWIFGVLHVV--------HASVVTAYLFTVSNAFQGMFIF-LFL 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl4NP_788394.1 Methuselah_N 23..201 CDD:284145 29/136 (21%)
7tm_4 213..>385 CDD:304433 50/194 (26%)
Adgrl4NP_573485.2 EGF_CA 58..91 CDD:214542
EGF_CA 108..141 CDD:214542
GAIN 190..370 CDD:293098
GPS 417..461 CDD:280071 14/59 (24%)
7tm_4 473..709 CDD:304433 69/284 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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