DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl4 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	391	Identity:	100/391 - (25%)
Similarity:	160/391 - (40%)	Gaps:	88/391 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 VVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNE--------FTLFENGSLLRHWD----KVEL 177
            ||.....:|:.:| :||.   |.:..|.| :.||:        |..|||.:.|..|:    ||:.
Human  2649 VVSASISDDMFIQ-NLAD---PVVITLQH-IGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKE 2708

  Fly   178 SKREYCV---QHLSFKDDSIRIAPHFCPL-----SSEHSRTWKTVAIV------ISLICIILTIS 228
            :...|.:   .||:          ||..|     |:..|...:.:|::      ||.|.:.:.:.
Human  2709 TNVNYTICQCDHLT----------HFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVV 2763

  Fly   229 VYLYVEKLRNLHGKCFICYL--ASLFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVMAAFFWL 288
            .|:...|||..:....:..|  |.|.|...||: |.|..|   .|.|:||....::.::.:|.|:
Human  2764 TYIAFHKLRKDYPAKILINLCTALLMLNLVFLI-NSWLSSFQKVGVCITAAVALHYFLLVSFTWM 2827

  Fly   289 SVIGIHLRIKFSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKNE---KLRPRVG 350
            .:..:|:.:......|.   .:| |....:.|..||||.||.|||.:    ||.:   .|.|...
Human  2828 GLEAVHMYLALVKVFNI---YIP-NYILKFCLVGWGIPAIMVAITVS----VKKDLYGTLSPTTP 2884

  Fly   351 VGKNCWIYTGD---MTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQIND 412
            .   |||....   ::|:.||    .|:...|:.||....:.:    .:||..:.|.:....::|
Human  2885 F---CWIKDDSIFYISVVAYF----CLIFLMNLSMFCTVLVQL----NSVKSQIQKTRRKMILHD 2938

  Fly   413 QQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARA----LMVADYFNWSQGTIIFVLF-ILKPS 472
            .:.   .:.|..|:||:|.|...        ||...    |.:...||..||..|||.. ::|.|
Human  2939 LKG---TMSLTFLLGLTWGFAFF--------AWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKES 2992

  Fly   473 I 473
            :
Human  2993 V 2993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	23/90 (26%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	51/188 (27%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071	13/52 (25%)
		7tm_2	2743..2982	CDD:278432	68/269 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810