Protein Alignment mthl4 and adgrf3a

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_021322955.1
• Gene: adgrf3a / 101886922
• ZFINID: ZDB-GENE-131121-607
• Length: 949
• Species: Danio rerio
• Alignment Length: 542
• Identity: 106/542 - (19%)
• Similarity: 197/542 - (36%)
• Gaps: 168/542 - (30%)

  Fly    16 SNAEIPGCDFFDTVDISK----APRFSNGSYLYEGL-----LIPAHLTAEYDYKLLADDSKEKVA 71
            |||::..|:.....||.|    :.|.|:.|.:..|.     ::|         |...:||...:
Zfish   517 SNAQMALCNHTSPADICKTFNASVRNSDNSVVVFGFRNLYQILP---------KAEGNDSNTTI- 571

  Fly    72 SHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRR-------- 128
                                            :|...:|.::...::||...|..:|
Zfish   572 --------------------------------LSVTPVNANNTNRSITLEFDSAKQRLPNHMIYC 604

  Fly   129 -HFKEDLIVQSDLAKPGC-------PRMYFLNHELPGNEFTLF--ENGSLLRHWDKVELSKREYC 183
             ::.|:|   ::.:..||       |.:...:|   .:.||:.  :|...|.:.|::
Zfish   605 VYWDENL---NEWSSDGCRWAGVDNPTLCICDH---NSAFTILMSKNAETLPYMDEL-------- 655

  Fly   184 VQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAI-VISLI-CIILTISVYLYVEK--LRNL-HGKC 243
                                      |:..:.| ::||: |:|:.:.|:..|.|  :.|. |...
Zfish   656 --------------------------TYAGLGISILSLLACLIIKVLVWDAVVKSPISNFRHVAL 694

  Fly   244 FICYLASLFLGYFFLVLNVWKYSS---GFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNC 305
            |...|..|.....||..:  |..|   .:|.....:.:|..:|.|||:      |.:.|.|
Zfish   695 FNISLCLLLAHCMFLTTS--KPESIPPNWCSILTLIKHFFFLAVFFWM------LCLSFVL---- 747

  Fly   306 LHRL------LPENPFRAYNL-YAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWI-YTGDM 362
            ||::      |.:..|...:: ..:..|:|..|:||    :..|............||: |.|.:
Zfish   748 LHQMIYVFDRLRKKVFLGLSITVGYACPIIAVAVTY----ISFNNGAEGEYYSKSTCWLTYKGTL 808

  Fly   363 TVMIYFYGPMLLLIAFNIIMFV-LSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILM 426
            ...|:.:     :|....|:|| |..:.:..:|.....:...:..:::...:.|....:.|..::
Zfish   809 KGSIFAF-----IIPIGAIVFVNLFTLAVVIMKIATPSISEAKARDEKDVAKSMIKTIVFLSPVL 868

  Fly   427 GLSW--SFEILSFLLTKQQAWARALMVADY--FNWSQGTIIFVLFI-------LKPSILKLIIAG 480
            ||||  .|.:|...|| .:.|| ||:...:  ||..||  :|:|..       ::.::||
Zfish   869 GLSWVLGFFVLGLDLT-VKPWA-ALVNYSFTIFNSLQG--LFILLTNCVGEKKVRDALLK----- 924

  Fly   481 GRQNLPGSHHNSRSKAARYNST 502
             |..:..|.|:....:::..|:
Zfish   925 -RFKIKQSVHSKTESSSKAQSS 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	29/204 (14%)
		7tm_4	213..>385	CDD:304433	45/188 (24%)
adgrf3a	XP_021322955.1	GPS	604..641	CDD:307782	8/42 (19%)
		7tm_GPCRs	649..926	CDD:333717	72/341 (21%)
		TM helix 1	652..676	CDD:320095	7/57 (12%)
		TM helix 2	691..712	CDD:320095	6/20 (30%)
		TM helix 3	723..745	CDD:320095	6/27 (22%)
		TM helix 4	766..782	CDD:320095	3/15 (20%)
		TM helix 5	805..831	CDD:320095	7/30 (23%)
		TM helix 6	855..881	CDD:320095	8/25 (32%)
		TM helix 7	890..915	CDD:320095	8/26 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810