Protein Alignment mthl4 and ADGRG2

DIOPT Version :9

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001073327.1
• Gene: ADGRG2 / 10149
• HGNCID: 4516
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 72/287 - (25%)
• Similarity: 119/287 - (41%)
• Gaps: 65/287 - (22%)

  Fly   218 ISLICIILTISVYLYVEKL-RNLHGKCFICYLASLFLGYFFLVLNVW--KYS-SGFCVT-AGFLG 277
            :|.|.:.:|:..|:..||: |:...|..|...|:|.|.....:|:.|  .|. .|.|:: |.||.
Human   638 LSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLH 702

  Fly   278 YFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFRAYNL----YAWGIPLIMTAITYTADQ 338
            || ::.:|.|:.:...|:.:......|..        .|.|.|    ..||:|.::..|..|
Human   703 YF-LLVSFTWMGLEAFHMYLALVKVFNTY--------IRKYILKFCIVGWGVPAVVVTIILT--- 755

  Fly   339 VVKNEKLRP-RVGVGKN-----------CWIYTGD---MTVMIYFYGPMLLLIAFNIIMFVLSAI 388
                  :.| ..|:|..           |||....   :||:.||    .::...|:.||::..:
Human   756 ------ISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYF----CVIFLLNVSMFIVVLV 810

  Fly   389 YIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARALMVAD 453
            .:..|||. |.|..:::|:  |.|.:..|   .|..|:|::|.|...        ||....:...
Human   811 QLCRIKKK-KQLGAQRKTS--IQDLRSIA---GLTFLLGITWGFAFF--------AWGPVNVTFM 861

  Fly   454 Y----FNWSQGTIIFVLF-ILKPSILK 475
            |    ||..||..||:.: :.|.::.|
Human   862 YLFAIFNTLQGFFIFIFYCVAKENVRK 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145
		7tm_4	213..>385	CDD:304433	47/190 (25%)
ADGRG2	NP_001073327.1	GPS	569..612	CDD:280071
		7tm_4	625..875	CDD:304433	68/272 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810