DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and adgre13

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021327151.1	Gene:	adgre13 / 100538238	ZFINID:	ZDB-GENE-150505-3	Length:	303	Species:	Danio rerio

Alignment Length:	267	Identity:	59/267 - (22%)
Similarity:	109/267 - (40%)	Gaps:	42/267 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 VAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGY-FFLV----LNVWKYSSGFCVTA 273
            |.:::.|:...|.:..:.:.:....::....|....||.|.: .||:    |::.:.....|...
Zfish    21 VCVIVGLLFFSLALLTFAFCQWGPGVNNVARINICISLLLAHLLFLLTQQFLSLIRRQQMLCEVI 85

  Fly   274 GFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRL-----LPENPFRAYNLYAWGIPLIMTAIT 333
            ..|.:|..::.|.|:.:..:.|.|       |:..|     ...|..|...|...|..:.:..:.
Zfish    86 SGLLHFLFLSGFVWMFIEAVLLFI-------CVKNLSQISSQKRNVLRNIFLCVIGYAVALVVVG 143

  Fly   334 YTADQVVKNEKLRPRVGVG-KNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNV 397
            .:|..|.|        |.| :.|||.. |...:..|.||:.:::|.|:|:|:...:.:.:..|.:
Zfish   144 ISAAVVPK--------GYGSEKCWIKM-DKGFIWSFLGPVTVILALNVILFIGIGVSLKSAFKKL 199

  Fly   398 KGLVHKQQTNQQINDQQMFAIF--LRLFILMGLSWSFEILSFLLTKQQAWARALMVADYFNWSQG 460
            ...|      .|:| |....:|  |..|:::|.||   ||.|.....:......::   .|..||
Zfish   200 NADV------SQLN-QTKIIMFKTLAQFVVLGCSW---ILGFFTNSSKVLEILFLI---LNSQQG 251

  Fly   461 TIIFVLF 467
            |.||:::
Zfish   252 TFIFLIY 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	39/181 (22%)
adgre13	XP_021327151.1	7tm_GPCRs	12..274	CDD:333717	59/267 (22%)
		TM helix 1	15..39	CDD:320095	3/17 (18%)
		TM helix 2	48..69	CDD:320095	6/20 (30%)
		TM helix 3	83..105	CDD:320095	4/21 (19%)
		TM helix 4	129..145	CDD:320095	2/15 (13%)
		TM helix 5	163..186	CDD:320095	7/22 (32%)
		TM helix 6	210..233	CDD:320095	9/25 (36%)
		TM helix 7	237..262	CDD:320095	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010