DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl4 and adgrf11

DIOPT Version :9

Sequence 1:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_005160858.1	Gene:	adgrf11 / 100537132	ZFINID:	ZDB-GENE-121214-165	Length:	691	Species:	Danio rerio

Alignment Length:	357	Identity:	76/357 - (21%)
Similarity:	130/357 - (36%)	Gaps:	87/357 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 VNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWD------K 174
            ||.||.:.|.|....::.|         |.|:..|.|..              |..||      |
Zfish   297 VNQTLQNISFVFDTTEQSL---------GNPQCVFWNFH--------------LSTWDSTGCEVK 338

  Fly   175 VELSKRE-------YCVQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAI-VISL-ICIILTISVY 230
            ..||:.|       .|....||   |:.::|.|....:....|:..:.| |:|| |.:|:...|:
Zfish   339 PNLSEEEKIDKITCECNHTTSF---SLLMSPFFIDDKALDYITYTGLGISVLSLVISLIIGAIVW 400

  Fly   231 LYVEKLRN--LHGKCFICYLASLFLGYFFLVLNVWKYSSGF------CVTAGFLGYFSVMAAFFW 287
            ..|.|..:  |...|.:....||.:.....::.......|.      |....|..:...:|.|||
Zfish   401 TTVTKSNSAYLRHVCLVNTNVSLLVADVCFIIGASIVQPGQLAPVGPCTAVAFSMHLFFLAFFFW 465

  Fly   288 LSVIGIHLRIKFSLASNCLHR--LLPENPFRAYNLYAWGIPLIMTAITY--TADQVVKNEKLRPR 348
            :.:..:.|....::..:.:.|  ::....|..|     |.||::..|||  ||.:
Zfish   466 MLISAMLLLYMTTMVYSQMSRAKMMAIAFFLGY-----GAPLLIVVITYGLTARE---------- 515

  Fly   349 VGVGKN------CWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTN 407
               ||.      ||:...:...:..|........|.|:::.:   :.:|      |.|:.::|.|
Zfish   516 ---GKYILEADVCWLNFDETKALQIFVSLASSFTAVNVLIII---VVLY------KMLIVRKQQN 568

  Fly   408 QQIND-QQMFAIFLRLFILMGLSWSFEILSFL 438
            ::.|. ..:..:.|.:..|.|::|...|.:.|
Zfish   569 KETNILPTVTRVVLIVSPLFGVTWGLGIGTML 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	23/97 (24%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	39/191 (20%)
adgrf11	XP_005160858.1	GAIN	143..>227	CDD:293098
		GPS	318..363	CDD:280071	14/61 (23%)
		7tm_4	374..620	CDD:304433	52/254 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810