DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl4 and gpr157

DIOPT Version :9

Sequence 1:NP_788394.1 Gene:mthl4 / 36960 FlyBaseID:FBgn0034219 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_001124512.1 Gene:gpr157 / 100038048 XenbaseID:XB-GENE-492646 Length:323 Species:Xenopus tropicalis


Alignment Length:333 Identity:80/333 - (24%)
Similarity:137/333 - (41%) Gaps:80/333 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 IVISLICII------LTISVYLYVEKLRNLHGKCFICYL--ASLF--LGYFFLVLNVWKYSSGFC 270
            :::.|.|::      |.|..|:..:.||: ..:..:.:|  |.|.  |.||:.||..::.|:..|
 Frog    17 VIVLLSCVLSFLGSALIIVTYILWQDLRS-RPRLLLLFLSVADLLSALSYFYGVLRNFQDSTWDC 80

  Fly   271 VTAGFLGYFSVMAAFFWLSVIGIHLRIKF-----SLASNCLHRLLPENPFRAYNLYAWGIPLIMT 330
            ||.|.:..||..::|||...:.::|.|..     |.|...:..|         :|.:||:||::|
 Frog    81 VTQGAISTFSNTSSFFWTVAVAVYLYITIVKSQQSFADQIIPWL---------HLISWGVPLVIT 136

  Fly   331 -------AITYTADQVVKNEKLRPRVGVGKNCW--IYTGDMTVMIYFYGPMLLLIAFNIIMFVLS 386
                   .|.|.|..          |.||. ||  |...|..:.:...|.:..::|:    .:|.
 Frog   137 LSAVCLKKIGYDASY----------VSVGW-CWVKIDVEDKLLWMLLAGKVWEILAY----LILP 186

  Fly   387 AIYIYNIKKNVKGLVH-----------KQQTNQ--QINDQQMFAIFLRLFILMGLSWSFEILSFL 438
            .:||. |||:: |..|           ....||  .|.|:::  :|:.:..:....||  .:.|:
 Frog   187 VLYIL-IKKHI-GRAHAALAEYRPILATSPVNQPRTIADKKL--VFIPIIFIFLRVWS--TIRFI 245

  Fly   439 LT--KQQAWARALMV-----ADYFNWSQGTIIFVLF--ILKPSILKLIIAGGRQNLPGSHHNSRS 494
            ||  ...|....::|     .:.|......|:|||.  :::..::.|:....|.:   ...|..|
 Frog   246 LTLCDSPAVHNPILVTLHGIGNTFQGGANCIMFVLCTPVIRSRLVSLLCGCSRSS---RRENETS 307

  Fly   495 KAARYNST 502
            ....|.||
 Frog   308 TRRTYGST 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl4NP_788394.1 Methuselah_N 23..201 CDD:284145
7tm_4 213..>385 CDD:304433 48/192 (25%)
gpr157NP_001124512.1 7tm_GPCRs 17..>192 CDD:391938 51/200 (26%)
TM helix 1 17..39 CDD:341315 5/21 (24%)
TM helix 2 48..69 CDD:341315 6/20 (30%)
TM helix 3 81..103 CDD:341315 8/21 (38%)
TM helix 4 123..139 CDD:341315 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 49 1.000 Inparanoid score I5275
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.960

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