DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITGB8 and Itgbn

DIOPT Version :9

Sequence 1:	NP_002205.1	Gene:	ITGB8 / 3696	HGNCID:	6163	Length:	769	Species:	Homo sapiens
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	237/830 - (28%)
Similarity:	363/830 - (43%)	Gaps:	137/830 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    22 GPASFLWAAWVFSLVLGLGQGE----DNRCASSNAASCARCLALGPECGWCVQEDFISGGSRSER 82
            |..:|||...|| |:..:...:    |::|  .:|.||.|||:...||.||..:::..|    .|
  Fly     5 GGRAFLWIYLVF-LIAEISHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEYQVG----YR 62

Human    83 CDIVSNLISKGCSVDSI--EYPSVHVI-------IPTENEINTQVTPGEVSIQLRPGAEANFMLK 138
            |.....|::..||...|  ..|.:.|:       ..|.::. .||||....::|..|......|.
  Fly    63 CLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQA-VQVTPQRAYLKLVKGNTQRMKLS 126

Human   139 VHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIH 203
            ....:..|:|||.|:|::.:|.::.:.|..:|..||:.:...:.::||||||:.||...|.|.
  Fly   127 YRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL-- 189

Human   204 PERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCES 268
            |:...|.|:.....|.|.:||.|.||||::|..|..||...||:||:|..|||.||::|..||..
  Fly   190 PQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTK 254

Human   269 HIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHL-KNNVYVKSTTMEHPSLGQLSEKL 332
            .|||:::|:::::::||...|||.|..||||:..||..||| |...|..|...::|||.::..:|
  Fly   255 EIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYREL 319

Human   333 IDNNINVIFAVQGKQFHWYKDLLPLLPG-TIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQV 396
            :...|||||||..:....|.:|..|:.. :....:.:.::|:..|:.::|:.||...:. .:|..
  Fly   320 LRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSP 383

Human   397 QGIYFNITAICPDGSRKPGMEG---CRNVTSNDEVLFNVTVTMKKCDVTGGKNYAIIKPIGFNET 458
            ..|.......|  |.:.|.::.   |.|||...::.|.|.||:||..    .|......|...||
  Fly   384 DFIDMAYYTDC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYP----DNQVYTHKIRVEET 442

Human   459 A-------KIHIHRNCSCQ-CEDNRGPKGK--CVDETFLDSKCFQCDEN------KCHFDEDQFS 507
            :       .:.:.|.|.|| ..|....:|:  |..:.:|.....:|||.      .|..|....:
  Fly   443 SLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVT 507

Human   508 S-----ESCKSHKDQP---------VCSGRGVCVCGKCSCHKIKLGKVYGKYCE-KDDFSCPYHH 557
            |     :.|:    ||         |||..|.|.||.|.|..    ...|.:|| ::...|.
  Fly   508 SNEALLQKCR----QPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCECRECLDCD--- 561

Human   558 GNLCAGHGECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGR 622
                ....:|..|:|.|..||.|.:|.| ......||...|::||.||||.|..|:|.:| .:|:
  Fly   562 ----EKLADCFCGQCVCKYGWSGSKCNC-DGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGK 620

Human   623 FC--------------EHCPTCYTACKENWNCMQCL------------HPHNLSQAI---LDQCK 658
            ||              |.|.||....|:.....:.|            :|:|....:   .|||.
  Fly   621 FCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQDQCL 685

Human   659 T--------SCALMEQQHYVD-------QTSECFSSPSYLRIFFIIFIVTFLIGLLKVLIIRQVI 708
            .        .|........:|       |..:| ..|.|:.:...|...|.|||||.:.||...|
  Fly   686 VRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYI 749

Human   709 LQWNSNKIKSSSDY-RVSASKKDKLILQSVCTRAVTYRREKPE--EIKMD 755
                  :.|.:.:| :....:|:.:..::...|....|.|.|:  .:|.|
  Fly   750 ------RAKDAREYAKFEEDQKNSVRQENPIYRDPVGRYEVPKALSVKYD 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITGB8	NP_002205.1	INB	54..469	CDD:197563	138/435 (32%)
ITGB8	NP_002205.1	Cysteine-rich tandem repeats	471..629		53/194 (27%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	138/435 (32%)
		EGF_2	524..552	CDD:285248	10/31 (32%)
		Integrin_b_cyt	748..785	CDD:285884	7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850