DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and Actl6b

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_006504698.1	Gene:	Actl6b / 83766	MGIID:	1933548	Length:	434	Species:	Mus musculus

Alignment Length:	444	Identity:	244/444 - (54%)
Similarity:	322/444 - (72%)	Gaps:	29/444 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGTMLYGGDEIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPE-TNLDPETKTDNNAT 64
            ||||  :|||||:||||||.|..|:|.|||.||.|||:.|:.||:.||.| ..|:.|.:.:...
Mouse     1 MSGG--VYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKG- 62

  Fly    65 PNNADQRKFYVDTNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSE 129
                  :.|::|||.:.|||...||.:.:|:|||::|:.|..::|:.|:..::|||..||||.||
Mouse    63 ------KIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSE 121

  Fly   130 ASWNVRNNREKLTELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLS 194
            |.||.|..||||||||||:||:|||||.|.|||.||::||:|.||:|||||||:|:|||:||||.
Mouse   122 APWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQ 186

  Fly   195 QAVVKSPLGGDFLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLR-KLPENLTQSWQNY 258
            |.:|||||.|||:|.|||:..::..||:.|.|.||:|:.|:|.....:..: |||: :::||.||
Mouse   187 QGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQ-VSKSWHNY 250

  Fly   259 MLQLMMQDFQMNVLQVLENPFDERVAAQIPTVHYEFPNGYHQDFGSERFKIAESLFD-------- 315
            |...::||||.:||||.::|:||:||||:||||||.||||:.|:|:||.:|.|.|||
Mouse   251 MCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLS 315

  Fly   316 -NAMLGAGQLASTSVGMCDADVR--------LSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSN 371
             |.|||.|.:.:||:||||.|:|        ..|:|||:|||||||||||.:||||:|..:.|.:
Mouse   316 GNTMLGVGHVVTTSIGMCDIDIRPVDASPCSQGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPS 380

  Fly   372 TRLKMISANGSVERRFGAWIGGSILASIGTFQQMWISSQEYEEAGKSQVERKCP 425
            .|||:|::|.::||:|..|||||||||:|||||||||.|||||.||..||||||
Mouse   381 MRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	233/430 (54%)
Actl6b	XP_006504698.1	Actin	11..434	CDD:306521	233/430 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I409
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1388
Isobase	1	0.950	-	0	Normalized mean entropy	S833
OMA	1	1.010	-	-		QHG55702
OrthoDB	1	1.010	-	-		D300517at33208
OrthoFinder	1	1.000	-	-		FOG0001878
OrthoInspector	1	1.000	-	-		otm43369
orthoMCL	1	0.900	-	-		OOG6_102754
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4301
SonicParanoid	1	1.000	-	-		X1579
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.820