DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and POTEJ

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_011509985.1	Gene:	POTEJ / 653781	HGNCID:	37094	Length:	1048	Species:	Homo sapiens

Alignment Length:	419	Identity:	130/419 - (31%)
Similarity:	211/419 - (50%)	Gaps:	52/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DEIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPETNLDPETKTDNNATPNNADQRKFYV 75
            |:...||.|.|....:.|:|.:|:|:|..||:||   .|.          .........|::.||
Human   676 DDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVG---CPR----------QQGMMGGMHQKESYV 727

  Fly    76 DTNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSEASWNVRNNREK 140
            ... ....|..:.::..|:.|:|.|||..||:..:.:.|.::..||.||:|.:||..|.:.||||
Human   728 GKE-AQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREK 791

  Fly   141 LTELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLSQAVVKSPLGGD 205
            :|::|||.:|.||.::...|:|:.::|||.|.:|:|||...|..||:::|..|..|.::..|.|.
Human   792 MTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGR 856

  Fly   206 FLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLRKLPENLTQSWQNYMLQLMMQDFQMN 270
            .|:....:.|.:.|...:   .:|.:::|          |.:.|.|.         .:..||:..
Human   857 ELTDYLMKILTERGYRFT---TMAEREIV----------RDIKEKLC---------YVALDFEQE 899

  Fly   271 VLQVLENPFDERVAAQIPTVHYEFPNGYHQDFGSERFKIAESLFDNAML-----GAGQLASTSVG 330
            :..|..:...|:        .||.|:|......:|.|:..|:||....|     |..:....|:.
Human   900 MAMVASSSSLEK--------SYELPDGQVITISNEWFRCPEALFQPCFLGMESCGIHETTFNSIM 956

  Fly   331 MCDADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLKMISANGSVERRFGAWIGGSI 395
            ..|.|:|..|:.:.|::||.|:..|...|:.:::...|||..::::|:   ..:|::..|:||||
Human   957 KSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIA---PPKRKYSVWVGGSI 1018

  Fly   396 LASIGTFQQMWISSQEYEEAGKSQVERKC 424
            |||:.||||||||.|||:|:|.|.|.|||
Human  1019 LASLSTFQQMWISKQEYDESGPSIVHRKC 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	129/417 (31%)
POTEJ	XP_011509985.1	Ank_2	106..209	CDD:289560
		ANK	130..265	CDD:238125
		ANK repeat	137..166	CDD:293786
		ANK repeat	168..209	CDD:293786
		ANK	206..330	CDD:238125
		ANK repeat	211..242	CDD:293786
		Ank_2	216..308	CDD:289560
		ANK repeat	244..275	CDD:293786
		ANK repeat	277..308	CDD:293786
		NBD_sugar-kinase_HSP70_actin	674..1048	CDD:302596	130/419 (31%)
		ACTIN	678..1048	CDD:214592	129/417 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820