DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and actl6b

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_005170633.1	Gene:	actl6b / 553775	ZFINID:	ZDB-GENE-050522-191	Length:	426	Species:	Danio rerio

Alignment Length:	435	Identity:	247/435 - (56%)
Similarity:	320/435 - (73%)	Gaps:	19/435 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGTMLYGGDEIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPETNLDPETKTDNNATP 65
            ||||  :|||||:||||||.|..|.|.|||.||.|||:.|:.:|:.|..|...|...:.::|:
Zfish     1 MSGG--VYGGDEVGALVFDIGSFSTRAGYAGEDCPKADFPTTIGVNAEEEGPADMGVEQESNS-- 61

  Fly    66 NNADQRKFYVDTNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSEA 130
                .|.:|:||..:.|||:.:|:.:.:|:|||::||.|:.:||:.|:..|:|||..||||.|||
Zfish    62 ----GRSYYIDTTALHVPRAGVELISPLKNGMIEDWDAFQAIIDHIYSKHIKSEPGLHPVLMSEA 122

  Fly   131 SWNVRNNREKLTELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLSQ 195
            .||.|..|||||||:||.||:|||||.|.|||.||::||||.||:|||||||:|:|||:||||.|
Zfish   123 PWNSRAKREKLTELIFEHYNIPAFFLCKTAVLTAFANGRATGLVLDSGATHTTAIPVHDGYVLQQ 187

  Fly   196 AVVKSPLGGDFLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLR-KLPENLTQSWQNYM 259
            .:|||||.|||:|.|||:..::..||..|.|.||||:.|:|.....:|.: |||. :::||..:|
Zfish   188 GIVKSPLAGDFISMQCRELFQEMNIDTVPSYMIASKEPVREGAPAMWTKKDKLPP-VSKSWHTFM 251

  Fly   260 LQLMMQDFQMNVLQVLENPFDERVAAQIPTVHYEFPNGYHQDFGSERFKIAESLFD--------- 315
            ...::||||.:||||.::|:||:||||:||||||.|:||..|||:||.:|.|.|||
Zfish   252 CNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPSGYSTDFGAERLRIPEGLFDPSNVKGLSG 316

  Fly   316 NAMLGAGQLASTSVGMCDADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLKMISAN 380
            |.|||.|.:.:||:||||.|:|..|:|||:|||||||||||.|||||:|..:||.:.|||:|:.|
Zfish   317 NTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTERLNRELSQKAPPSMRLKLIACN 381

  Fly   381 GSVERRFGAWIGGSILASIGTFQQMWISSQEYEEAGKSQVERKCP 425
            .|:||||.:|||||||||:|||||||||.|||:|.||..||||||
Zfish   382 SSIERRFSSWIGGSILASLGTFQQMWISKQEYDEGGKQSVERKCP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	236/421 (56%)
actl6b	XP_005170633.1	NBD_sugar-kinase_HSP70_actin	10..425	CDD:302596	236/421 (56%)
actl6b	XP_005170633.1	Actin	11..426	CDD:278451	236/421 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	495	1.000	Domainoid score	I347
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1290
OMA	1	1.010	-	-		QHG55702
OrthoDB	1	1.010	-	-		D300517at33208
OrthoFinder	1	1.000	-	-		FOG0001878
OrthoInspector	1	1.000	-	-		otm25738
orthoMCL	1	0.900	-	-		OOG6_102754
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4301
SonicParanoid	1	1.000	-	-		X1579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870